HGNC ID: 6023
Target Abstract:
Interleukin 7 (IL-7) is a hematopoietic growth factor secreted by bone marrow and thymic stromal cells, and is also produced by keratinocytes, dendritic cells, hepatocytes, neurons, and epithelial cells, but normal lymphocytes do not produce IL-7. IL-7 stimulates the differentiation of pluripotent hematopoietic stem cells to lymphoid progenitors, and similarly stimulates the proliferation of cells of all lymphoid lineages (B cells, T cells, and NK cells). IL-7 promotes the development of malignant hematologic diseases (acute lymphoblastic leukemia, T-cell lymphoma), elevated levels of IL-7 are detected in the plasma of HIV-infected patients, and IL-7 also enhances immune recovery after allogeneic stem cell transplantation.
IL7 Target Infomation Overview
- Target Symbol: IL7, interleukin 7
- Gene Groups: Interleukins
- Alias: IL-7
IL7, interleukin 7 Target Infomation by Species
- Human
- Mouse
- Rat
Human IL7 Target Information
- Target Symbol: IL7, interleukin 7
- Alias:
- IL-7
- IL7 nirs variant 6
- NCBI_Gene: 3574
- UniProtKB: P13232
Human IL7 Predicted Functions
Enables cytokine activity. Involved in cytokine-mediated signaling pathway; positive regulation of chemokine production; and positive regulation of cytokine-mediated signaling pathway. Located in extracellular region. Part of collagen-containing extracellular matrix. Implicated in epidermodysplasia verruciformis. Biomarker of Alzheimer’s disease and COVID-19.
Mouse Il7 Target Information
- Target Symbol: Il7, interleukin 7
- Alias:
- A630026I06Rik
- heart, lung and blood 368
- hlb368
- Il-7
- RIKEN cDNA A630026I06 gene
- NCBI_Gene: 16196
Mouse Il7 Predicted Functions
Enables cytokine activity and growth factor activity. Acts upstream of or within several processes, including negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of lymphocyte activation; and tissue homeostasis. Located in extracellular space. Is expressed in several structures, including brain; branchial arch; hemolymphoid system; intestine; and lymphatic system. Human ortholog(s) of this gene implicated in epidermodysplasia verruciformis. Orthologous to human IL7 (interleukin 7).
Rat Il7 Target Information
- Target Symbol: Il7, interleukin 7
- Alias:
- IL-7
- interleukin-7
- NCBI_Gene: 25647
Rat Il7 Predicted Functions
Predicted to enable cytokine activity and growth factor activity. Involved in cellular response to hypoxia and response to X-ray. Predicted to be located in extracellular space. Used to study high grade glioma. Biomarker of periodontal disease. Human ortholog(s) of this gene implicated in epidermodysplasia verruciformis. Orthologous to human IL7 (interleukin 7).
