HGNC ID: 16039
Target Abstract:
Angiopoietin-like protein, also known as angiopoietin-related protein, is structurally related to angiopoietin. In humans, angiopoietin-like protein 4 is a protein encoded by the ANGPTL4 gene. This gene was previously known as ANGPTL2, HFARP, PGAR, or FIAF, but has been renamed ANGPTL4.ANGPTL4 is a member of the angiopoietin-like gene family and encodes a secreted glycosylated protein.ANGPTL4 is highly expressed in adipose tissue. Expression is upregulated in endothelial cells and cardiomyocytes during hypoxia.ANGPTL4 is involved in the regulation of lipid and glucose metabolism, and it has also been implicated in angiogenesis.ANGPTL4 is also expressed in hypoxic human tissues, as well as in a variety of cancers such as liposarcoma, hepatocellular carcinoma, and conventional renal cell carcinoma.
ANGPTL4 Target Infomation Overview
- Target Symbol: ANGPTL4, angiopoietin like 4
- Gene Groups: Fibrinogen C domain containing; Angiopoietin like family
- Alias: pp1158; PGAR; ARP4; HFARP; FIAF; NL2
- Alias Names: fasting-induced adipose factor; hepatic angiopoietin-related protein; PPARG angiopoietin related protein; hepatic fibrinogen/angiopoietin-related protein; peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin-related protein; angiopoietin-related protein 4; angiopoietin-like 4
ANGPTL4, angiopoietin like 4 Target Infomation by Species
- Human
- Mouse
- Rat
Human ANGPTL4 Target Information
- Target Symbol: ANGPTL4, angiopoietin like 4
- Alias:
- angiopoietin-like 4
- angiopoietin-like protein 4
- angiopoietin-related protein 4
- ANGPTL2
- ARP4
- fasting-induced adipose factor
- FIAF
- HARP
- hepatic angiopoietin-related protein
- hepatic fibrinogen/angiopoietin-related protein
- HFARP
- NL2
- peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin-related protein
- PGAR
- pp1158
- PPARG angiopoietin related protein
- TGQTL
- UNQ171
- NCBI_Gene: 51129
- UniProtKB: Q9BY76
Human ANGPTL4 Predicted Functions
Enables identical protein binding activity. Involved in negative regulation of apoptotic process; negative regulation of lipoprotein lipase activity; and protein unfolding. Located in extracellular space.
Mouse Angptl4 Target Information
- Target Symbol: Angptl4, angiopoietin-like 4
- Alias:
- BK89
- FIAF
- HFARP
- NG27
- NCBI_Gene: 57875
Mouse Angptl4 Predicted Functions
Enables enzyme inhibitor activity. Involved in negative regulation of apoptotic process; negative regulation of lipoprotein lipase activity; and triglyceride homeostasis. Acts upstream of or within negative regulation of endothelial cell apoptotic process. Located in extracellular space. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; integumental system; and musculature. Orthologous to human ANGPTL4 (angiopoietin like 4).
Rat Angptl4 Target Information
- Target Symbol: Angptl4, angiopoietin-like 4
- Alias:
- angiopoietin-like protein 4
- angiopoietin-related protein 4
- hepatic fibrinogen/angiopoietin-related protein
- HFARP
- LOC362850
- NCBI_Gene: 362850
- UniProtKB: Q6TMA8
Rat Angptl4 Predicted Functions
Enables identical protein binding activity. Involved in response to hypoxia. Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Orthologous to human ANGPTL4 (angiopoietin like 4).
