HGNC ID: 3229
Target Abstract:
Epidermal growth factor (EGF) is a growth factor that stimulates cell growth, proliferation, and differentiation by binding to its receptor EGFR. EGF is a small molecular weight peptide that was purified from the mouse submandibular gland at the latest and subsequently found in many human tissues, including the submandibular and parotid glands. Salivary EGF regulated by inorganic iodine in the diet plays an important physiological role in maintaining the integrity of the Oro esophagus and gastric tissue. The physiological functions of saliva EGF include healing oral and gastric ulcers, inhibiting gastric acid secretion, stimulating DNA synthesis, and protecting the mucosa from harmful factors such as gastric acid, bile acid, pepsin, and trypsin in the cavity, as well as physical, chemical, and bacterial factors. Enhanced EGF receptor activity can be observed in certain cancers typically associated with receptor mutations and functional abnormalities, such as compositional receptor signaling that is not dependent on EGF levels or binds to EGF.
EGF Target Infomation Overview
- Target Symbol: EGF, epidermal growth factor
- Alias Names: Pro-epidermal growth factor; epidermal growth factor (beta-urogastrone)
EGF, epidermal growth factor Target Infomation by Species
- Human
- Mouse
- Rat
Human EGF Target Information
- Target Symbol: EGF, epidermal growth factor
- Alias:
- beta-urogastrone
- HOMG4
- pro-epidermal growth factor
- URG
- NCBI_Gene: 1950
- UniProtKB: P01133
Human EGF Predicted Functions
Enables growth factor activity and guanyl-nucleotide exchange factor activity. Involved in several processes, including ERK1 and ERK2 cascade; positive regulation of macromolecule metabolic process; and positive regulation of signal transduction. Acts upstream of or within positive regulation of cell population proliferation. Located in extracellular exosome. Implicated in several diseases, including Zollinger-Ellison syndrome; hepatobiliary system cancer (multiple); high grade glioma (multiple); lung non-small cell carcinoma (multiple); and primary hypomagnesemia (multiple). Biomarker of several diseases, including acute kidney failure; lupus nephritis; neurodegenerative disease (multiple); pancreatic cancer (multiple); and pancreatitis.
Mouse Egf Target Information
- Target Symbol: Egf, epidermal growth factor
- Alias:
- AI790464
- expressed sequence AI790464
- NCBI_Gene: 13645
Mouse Egf Predicted Functions
Enables epidermal growth factor receptor binding activity. Involved in several processes, including negative regulation of cholesterol efflux; positive regulation of ubiquitin-dependent protein catabolic process; and regulation of receptor signaling pathway via JAK-STAT. Acts upstream of or within several processes, including mammary gland alveolus development; positive regulation of cerebellar granule cell precursor proliferation; and positive regulation of protein tyrosine kinase activity. Located in extracellular space and plasma membrane. Is expressed in several structures, including 1st branchial arch; alimentary system; brain; genitourinary system; and liver and biliary system. Human ortholog(s) of this gene implicated in several diseases, including Zollinger-Ellison syndrome; hepatobiliary system cancer (multiple); high grade glioma (multiple); lung non-small cell carcinoma (multiple); and primary hypomagnesemia (multiple). Orthologous to human EGF (epidermal growth factor).
Rat Egf Target Information
- Target Symbol: Egf, epidermal growth factor
- Alias:
- LOC103691699
- pro-epidermal growth factor
- uncharacterized LOC103691699
- NCBI_Gene: 25313
Rat Egf Predicted Functions
Enables epidermal growth factor receptor binding activity. Involved in several processes, including positive regulation of DNA biosynthetic process; positive regulation of ERK1 and ERK2 cascade; and positive regulation of fibroblast proliferation. Acts upstream of or within regulation of protein transport. Located in extracellular space. Used to study perinatal necrotizing enterocolitis. Biomarker of acute kidney failure. Human ortholog(s) of this gene implicated in several diseases, including Zollinger-Ellison syndrome; hepatobiliary system cancer (multiple); high grade glioma (multiple); lung non-small cell carcinoma (multiple); and primary hypomagnesemia (multiple). Orthologous to human EGF (epidermal growth factor).
