HGNC ID: 8760
Target Abstract:
CD279, also known as programmed cell death Protein 1(PD-1), is encoded by the PDCD1 gene. PD1 is a member of the immunoglobulin superfamily and belongs to the CD28 superfamily with CD28, CTLA-4 and ICOS molecules. Pd1 is mainly expressed in activated CD4+T and CD8+T cells and B cells in the form of monomers, and its ligands are B7-H1 and B7-DC. Studies have confirmed that enhancing PD-1 signaling can downregulate the response of activated T and B cells in peripheral tissues, and play an important role in maintaining peripheral T and B cell tolerance.
PDCD1 Target Infomation Overview
- Target Symbol: PDCD1, programmed cell death 1
- Gene Groups: CD molecules; V-set domain containing
- Alias: CD279; PD1; hSLE1; PD-1
- Previous Names: SLEB2
- Alias Names: systemic lupus erythematosus susceptibility 2
PDCD1, programmed cell death 1 Target Infomation by Species
- Human
- Mouse
- Rat
Human PDCD1 Target Information
- Target Symbol: PDCD1, programmed cell death 1
- Alias:
- CD279
- hPD-1
- hPD-l
- hSLE1
- PD-1
- PD1
- programmed cell death protein 1
- SLEB2
- systemic lupus erythematosus susceptibility 2
- NCBI_Gene: 5133
- UniProtKB: Q15116
Human PDCD1 Predicted Functions
Involved in positive regulation of T cell apoptotic process. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Implicated in autoimmune disease (multiple); hepatitis B; hepatitis C; hepatocellular carcinoma; and lupus nephritis. Biomarker of several diseases, including Cryptococcal meningitis; anogenital venereal wart; cervix uteri carcinoma in situ; liver disease (multiple); and tuberculosis (multiple).
Mouse Pdcd1 Target Information
- Target Symbol: Pdcd1, programmed cell death 1
- Alias:
- PD-1
- Pdc1
- programmed cell death
- NCBI_Gene: 18566
Mouse Pdcd1 Predicted Functions
Involved in negative regulation of immune response. Acts upstream of or within negative regulation of apoptotic process; negative regulation of tolerance induction; and positive regulation of apoptotic process. Located in external side of plasma membrane. Is expressed in retina. Used to study dilated cardiomyopathy and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); hepatitis B; hepatitis C; hepatocellular carcinoma; and lupus nephritis. Orthologous to human PDCD1 (programmed cell death 1).
Rat Pdcd1 Target Information
- Target Symbol: Pdcd1, programmed cell death 1
- Alias:
- LOC102550808
- LOC301626
- programmed cell death protein 1
- programmed cell death protein 1-like
- NCBI_Gene: 301626
- UniProtKB: D3ZIN8
Rat Pdcd1 Predicted Functions
Predicted to be involved in negative regulation of immune response and positive regulation of T cell apoptotic process. Predicted to act upstream of or within negative regulation of apoptotic process; negative regulation of tolerance induction; and positive regulation of apoptotic process. Located in plasma membrane. Biomarker of anti-basement membrane glomerulonephritis; periodontitis; and pre-eclampsia. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); hepatitis B; hepatitis C; hepatocellular carcinoma; and lupus nephritis. Orthologous to human PDCD1 (programmed cell death 1).
