HGNC ID: 11925
Target Abstract:
Tumor necrosis factor-associated apoptosis-inducing ligand (TRAIL), also known as CD253 or TNFSF10, is produced and secreted by most normal tissue cells. TRAIL binds to the death receptors DR4(TRAil-RI) and DR5(TRAil-RII). The process of apoptosis depends on caspase-8. Caspase-8 activates downstream caspases, including procaspase-3, 6, and 7, activating specific kinases. TRAIL also binds to receptors DcR1 that do not contain cytoplasmic regions and DcR2 that contain truncated death domains. DcR1 can act as TRAIL neutralizing receptor. The cytoplasmic region of DcR2 is functional and can activate NF-κB. Thus, in DCR2-expressing cells, TRAIL binding activates NF-κB, resulting in transcription of genes that antagonize death signaling pathways and/or promote inflammation.
TNFSF10 Target Infomation Overview
- Target Symbol: TNFSF10, TNF superfamily member 10
- Gene Groups: CD molecules; Tumor necrosis factor superfamily
- Alias: TRAIL; Apo-2L; TL2; CD253
- Alias Names: tumor necrosis factor (ligand) superfamily, member 10
TNFSF10, TNF superfamily member 10 Target Infomation by Species
- Human
- Mouse
- Rat
Human TNFSF10 Target Information
- Target Symbol: TNFSF10, TNF superfamily member 10
- Alias:
- Apo-2 ligand
- Apo-2L
- APO2L
- CD253
- chemokine tumor necrosis factor ligand superfamily member 10
- TL2
- TNF-related apoptosis inducing ligand TRAIL
- TNF-related apoptosis-inducing ligand
- TNLG6A
- TRAIL
- tumor necrosis factor (ligand) family, member 10
- tumor necrosis factor (ligand) superfamily member 10
- tumor necrosis factor (ligand) superfamily, member 10
- tumor necrosis factor apoptosis-inducing ligand splice variant delta
- tumor necrosis factor ligand 6A
- tumor necrosis factor ligand superfamily member 10
- tumor necrosis factor superfamily member 10
- NCBI_Gene: 8743
- UniProtKB: P50591
Human TNFSF10 Predicted Functions
Enables identical protein binding activity and zinc ion binding activity. Involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of release of cytochrome c from mitochondria; and positive regulation of signal transduction. Located in extracellular exosome. Implicated in arteriosclerosis and small cell carcinoma. Biomarker of type 1 diabetes mellitus.
Mouse Tnfsf10 Target Information
- Target Symbol: Tnfsf10, tumor necrosis factor (ligand) superfamily, member 10
- Alias:
- A330042I21Rik
- AI448571
- APO-2L
- expressed sequence AI448571
- RIKEN cDNA A330042I21 gene
- TNF-related apoptosis inducing ligand
- Trail
- NCBI_Gene: 22035
Mouse Tnfsf10 Predicted Functions
Enables TRAIL binding activity and tumor necrosis factor receptor superfamily binding activity. Acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway. Predicted to be located in extracellular space and plasma membrane. Predicted to be integral component of membrane. Is expressed in central nervous system; genitourinary system; gut; and retina. Human ortholog(s) of this gene implicated in arteriosclerosis and small cell carcinoma. Orthologous to human TNFSF10 (TNF superfamily member 10).
Rat Tnfsf10 Target Information
- Target Symbol: Tnfsf10, TNF superfamily member 10
- Alias:
- 4-1BB
- LOC500590
- MGC114552
- similar to T-cell antigen 4-1BB precursor – mouse
- tumor necrosis factor receptor superfamily member 9
- tumor necrosis factor receptor superfamily, member 9
- NCBI_Gene: 246775
- UniProtKB: E9PU84
Rat Tnfsf10 Predicted Functions
Predicted to enable cytokine binding activity; identical protein binding activity; and signaling receptor activity. Predicted to be involved in regulation of cell population proliferation. Predicted to act upstream of or within negative regulation of interleukin-10 production and negative regulation of interleukin-12 production. Predicted to be located in extracellular space and plasma membrane. Predicted to be active in external side of plasma membrane. Orthologous to human TNFRSF9 (TNF receptor superfamily member 9).
