HGNC ID: 3708
Target Abstract:
Vascular endothelial growth factor D (VEGF-D), also known as C-fos induced growth factor (FIGF), is a member of the PDGF/VEGF family and is active in vascular regeneration, lymphangiogenesis, and endothelial cell growth. The secreted protein undergoes a complex process of protein hydrolysis and maturation, forming various processing forms that can bind and activate VEGFR2 and VEGFR3 receptors. The structure and function of VEGF-D are similar to VEGF-C. VEGF is associated with various types of human malignant tumors. VEGF-D has been found to be overexpressed in various human tumor tissues and serum samples from patients. In addition, the expression of VEGF-D is associated with an increased incidence of regional lymph node metastasis. Experimental studies in mice have shown that transgenic tumor cells producing VEGF-D protein can enhance regional lymph node metastasis.
VEGFD Target Infomation Overview
- Target Symbol: VEGFD, vascular endothelial growth factor D
- Gene Groups: VEGF family
- Alias: VEGF-D
- Previous Names: FIGF
- Alias Names: c-fos induced growth factor (vascular endothelial growth factor D)
VEGFD, vascular endothelial growth factor D Target Infomation by Species
- Human
- Mouse
- Rat
Human VEGFD Target Information
- Target Symbol: VEGFD, vascular endothelial growth factor D
- Alias:
- c-fos induced growth factor
- c-fos induced growth factor (vascular endothelial growth factor D)
- c-fos-induced growth factor
- FIGF
- VEGF-D
- NCBI_Gene: 2277
- UniProtKB: O43915
Human VEGFD Predicted Functions
Enables chemoattractant activity and vascular endothelial growth factor receptor binding activity. Involved in induction of positive chemotaxis and positive regulation of mast cell chemotaxis. Predicted to be located in extracellular region and platelet alpha granule lumen. Predicted to be active in extracellular space. Biomarker of ovarian carcinoma and urinary bladder cancer.
Mouse Vegfd Target Information
- Target Symbol: Vegfd, vascular endothelial growth factor D
- Alias:
- c-fos induced growth factor
- Figf
- VEGF-D
- NCBI_Gene: 14205
Mouse Vegfd Predicted Functions
Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway and positive regulation of cell population proliferation. Located in extracellular space. Is expressed in several structures, including alimentary system; cerebellum; integumental system; limb; and skeleton. Orthologous to human FGF21 (fibroblast growth factor 21).
Rat Vegfd Target Information
- Target Symbol: Vegfd, vascular endothelial growth factor D
- Alias:
- c-fos induced growth factor
- c-fos induced growth factor (vascular endothelial growth factor D)
- c-fos-induced growth factor
- Figf
- Vegf-d
- NCBI_Gene: 360457
Rat Vegfd Predicted Functions
Enables vascular endothelial growth factor receptor binding activity. Involved in several processes, including positive regulation of interleukin-6 production; regulation of vascular endothelial growth factor receptor signaling pathway; and response to interleukin-1. Predicted to be located in extracellular space. Orthologous to human VEGFD (vascular endothelial growth factor D).
