The chemokine CC ligand 26 (CCL26) is a small molecular weight cytokine belonging to the CC chemokine family, also known as eosinophil-activated chemokine 3 (Eotaxin-3), macrophage inflammatory protein 4 alpha (MIP-4 alpha), thymic stromal chemokine 1 (TSC-1), and IMAC.It is expressed in a wide variety of tissues, including the heart, lungs, and ovary, and in IL-4-stimulated endothelial cells. Eotaxin-3 exerts chemotactic effects on eosinophils and basophils by binding to the cell-surface chemokine receptor CCR3.Eotaxin-3, along with Eotaxin-1 and Eotaxin-2, selectively activates CCR3.Eotaxin-3-CCR3 interaction has been shown to be important in the treatment of allergic diseases such as atopic dermatitis and bronchiolitis. reactive dermatitis and bronchial asthma.