HGNC ID: 10625
Target Abstract:
The chemokine CC ligand 26 (CCL26) is a small molecular weight cytokine belonging to the CC chemokine family, also known as eosinophil-activated chemokine 3 (Eotaxin-3), macrophage inflammatory protein 4 alpha (MIP-4 alpha), thymic stromal chemokine 1 (TSC-1), and IMAC.It is expressed in a wide variety of tissues, including the heart, lungs, and ovary, and in IL-4-stimulated endothelial cells. Eotaxin-3 exerts chemotactic effects on eosinophils and basophils by binding to the cell-surface chemokine receptor CCR3.Eotaxin-3, along with Eotaxin-1 and Eotaxin-2, selectively activates CCR3.Eotaxin-3-CCR3 interaction has been shown to be important in the treatment of allergic diseases such as atopic dermatitis and bronchiolitis. reactive dermatitis and bronchial asthma.
CCL26 Target Infomation Overview
- Target Symbol: CCL26, C-C motif chemokine ligand 26
- Gene Groups: Chemokine ligands
- Alias: MIP-4alpha; eotaxin-3; IMAC; MIP-4a; TSC-1
- Previous Names: SCYA26
- Alias Names: macrophage inflammatory protein 4-alpha; small inducible cytokine A26; CC chemokine IMAC; chemokine N1; thymic stroma chemokine-1; eotaxin-3; small inducible cytokine subfamily A (Cys-Cys), member 26; chemokine (C-C motif) ligand 26
CCL26, C-C motif chemokine ligand 26 Target Infomation by Species
- Human
- Mouse
- Rat
Human CCL26 Target Information
- Target Symbol: CCL26, C-C motif chemokine ligand 26
- Alias:
- C-C motif chemokine 26
- CC chemokine IMAC
- chemokine (C-C motif) ligand 26
- chemokine N1
- eotaxin-3
- IMAC
- macrophage inflammatory protein 4-alpha
- MGC126714
- MIP-4-alpha
- MIP-4a
- MIP-4alpha
- SCYA26
- small inducible cytokine A26
- small inducible cytokine subfamily A (Cys-Cys), member 26
- small-inducible cytokine A26
- thymic stroma chemokine-1
- TSC-1
- NCBI_Gene: 10344
- UniProtKB: Q9Y258
Human CCL26 Predicted Functions
Enables CCR3 chemokine receptor binding activity; CX3C chemokine receptor binding activity; and chemokine activity. Involved in several processes, including leukocyte chemotaxis; positive regulation of GTPase activity; and positive regulation of actin filament polymerization. Located in extracellular space. Implicated in asthma; eosinophilic esophagitis; and rhinitis. Biomarker of several diseases, including Churg-Strauss syndrome; dermatitis (multiple); eosinophilic esophagitis; eosinophilic gastroenteritis; and rhinitis (multiple).
Mouse Ccl26 Target Information
- Target Symbol: Ccl26, chemokine (C-C motif) ligand 26
- Alias:
- Ccl26l
- chemokine (C-C motif) ligand 26-like
- eotaxin-3
- NCBI_Gene: 541307
Mouse Ccl26 Predicted Functions
Predicted to enable CCR3 chemokine receptor binding activity; CX3C chemokine receptor binding activity; and chemokine activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; leukocyte chemotaxis; and positive regulation of ERK1 and ERK2 cascade. Predicted to be active in extracellular space. Is expressed in several structures, including aorta; bone marrow; brain; genitourinary system; and respiratory system. Human ortholog(s) of this gene implicated in asthma; eosinophilic esophagitis; and rhinitis. Orthologous to human CCL26 (C-C motif chemokine ligand 26).
Rat Ccl26 Target Information
- Target Symbol: Ccl26, C-C motif chemokine ligand 26
- Alias:
- C-C motif chemokine 26
- chemokine (C-C motif) ligand 26
- LOC685958
- similar to eotaxin 3-like
- NCBI_Gene: 685958
- UniProtKB: D3ZQG2
Rat Ccl26 Predicted Functions
Predicted to enable CCR3 chemokine receptor binding activity; CX3C chemokine receptor binding activity; and chemokine activity. Involved in response to organonitrogen compound. Predicted to be active in extracellular space. Used to study asthma. Human ortholog(s) of this gene implicated in asthma; eosinophilic esophagitis; and rhinitis. Orthologous to human CCL26 (C-C motif chemokine ligand 26).
