HGNC ID: 11766
Target Abstract:
Transforming growth factor β1 (TGF-β1) is a polypeptide member of the transforming growth factor β superfamily with a variety of cytological functions, including regulation of cell growth, proliferation, differentiation, and apoptosis. TGF-β and TGFA synergistically induce transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGF-β activation and signaling may lead to apoptosis. Many cells can synthesize TGF-β, and almost all have specific receptors. TGF-β1, TGF-β2, and TGF-β3 all function through the same receptor signaling pathway. TGF-β1 plays an important role in the regulation of the immune system and has different activities on different types of cells or cells at different stages of development. Most immune cells (or white blood cells) secrete TGF-β1. TGF-β1 is associated with cancer, autoimmune disease, liver disease, kidney disease, diabetes, cardiovascular disease, asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF).
TGFB1 Target Infomation Overview
- Target Symbol: TGFB1, transforming growth factor beta 1
- Gene Groups: Transforming growth factor beta family
- Alias: CED; TGFbeta
- Previous Names: TGFB; DPD1
- Alias Names: Camurati-Engelmann disease; prepro-transforming growth factor beta-1; Diaphyseal dysplasia 1, progressive; transforming growth factor, beta 1
TGFB1, transforming growth factor beta 1 Target Infomation by Species
- Human
- Mouse
- Rat
Human TGFB1 Target Information
- Target Symbol: TGFB1, transforming growth factor beta 1
- Alias:
- CED
- DPD1
- IBDIMDE
- LAP
- latency-associated peptide
- prepro-transforming growth factor beta-1
- TGF-beta 1 protein
- TGF-beta-1
- TGF-beta1
- TGFB
- TGFbeta
- transforming growth factor beta-1
- transforming growth factor beta-1 proprotein
- transforming growth factor beta1
- NCBI_Gene: 7040
- UniProtKB: P01137
Human TGFB1 Predicted Functions
Enables several functions, including antigen binding activity; identical protein binding activity; and transforming growth factor beta receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of macromolecule metabolic process; and positive regulation of signal transduction. Acts upstream of or within epithelial to mesenchymal transition; negative regulation of gene expression; and positive regulation of isotype switching to IgA isotypes. Located in several cellular components, including cell surface; extracellular space; and nucleus. Colocalizes with microvillus. Implicated in several diseases, including Behcet’s disease; Camurati-Engelmann disease; aphthous stomatitis; artery disease (multiple); and lung disease (multiple). Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); carcinoma (multiple); hematologic cancer (multiple); and lung disease (multiple).
Mouse Tgfb1 Target Information
- Target Symbol: Tgfb1, transforming growth factor, beta 1
- Alias:
- TGF-beta 1
- TGF-beta1
- Tgfb
- Tgfb-1
- TGFbeta1
- NCBI_Gene: 21803
Mouse Tgfb1 Predicted Functions
Enables protein serine/threonine kinase activator activity and transforming growth factor beta receptor binding activity. Involved in several processes, including circulatory system development; positive regulation of leukocyte differentiation; and regulation of cytokine production. Acts upstream of or within several processes, including animal organ development; positive regulation of histone modification; and regulation of protein localization to nucleus. Located in cytoplasm; extracellular matrix; and extracellular space. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; heart; and skin. Used to study Sjogren’s syndrome. Human ortholog(s) of this gene implicated in several diseases, including Behcet’s disease; Camurati-Engelmann disease; aphthous stomatitis; artery disease (multiple); and lung disease (multiple). Orthologous to human TGFB1 (transforming growth factor beta 1).
Rat Tgfb1 Target Information
- Target Symbol: Tgfb1, transforming growth factor, beta 1
- Alias:
- TGF-beta-1
- Tgfb
- transforming growth factor beta-1
- transforming growth factor beta-1 proprotein
- transforming growth factor, beta-1
- NCBI_Gene: 59086
- UniProtKB: P17246
Rat Tgfb1 Predicted Functions
Enables identical protein binding activity and protein N-terminus binding activity. Involved in several processes, including animal organ development; cellular response to hormone stimulus; and regulation of epithelial cell proliferation. Acts upstream of or within positive regulation of smooth muscle cell differentiation. Located in several cellular components, including cell surface; neuronal cell body; and secretory granule. Used to study chronic obstructive pulmonary disease; familial hyperlipidemia; hypertension; proteinuria; and pulmonary fibrosis. Biomarker of several diseases, including allergic rhinitis; artery disease (multiple); cerebrovascular disease (multiple); gastrointestinal system cancer (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including Behcet’s disease; Camurati-Engelmann disease; aphthous stomatitis; artery disease (multiple); and lung disease (multiple). Orthologous to human TGFB1 (transforming growth factor beta 1).
