HGNC ID: 9692
Target Abstract:
Pentraxin 3 (Pentraxin3), also known as tumor necrosis factor-inducible gene 14 (TSG-14), is a member of the pentraxin superfamily with a cyclic multimeric structure. Multiple cell types, especially mononuclear phagocytes, dendritic cells, fibroblasts, and endothelial cells, respond to initial inflammatory signals (e.g., toll-like receptors, TNF-α, IL-1β) by rapidly producing and releasing Pentraxin3. Pentraxin3 is an acute-phase response protein, which is normally present at low levels (about 25 ng/ ml and less than 2 ng/ml in humans) and is dramatically elevated (peaking 6-8 hours after induction) in endotoxic shock, sepsis, and other inflammatory and infectious conditions, with levels of up to 200-800 ng/ml, which correlate with the severity of the disease. In these conditions, Pentraxin3 is a rapid marker of innate immunity and local activation of the inflammatory response. Studies have shown that Pentraxin3 has a dual role: protection of the body against pathogens and modulation of autoimmunity.
PTX3 Target Infomation Overview
- Target Symbol: PTX3, pentraxin 3
- Gene Groups: Long pentraxins
- Alias: TSG-14
- Previous Names: TNFAIP5
- Alias Names: long pentraxin 3; pentaxin-related gene, rapidly induced by IL-1 beta; tumor necrosis factor, alpha-induced protein 5; pentraxin-related gene, rapidly induced by IL-1 beta; pentraxin 3, long
PTX3, pentraxin 3 Target Infomation by Species
- Human
- Mouse
- Rat
Human PTX3 Target Information
- Target Symbol: PTX3, pentraxin 3
- Alias:
- long pentraxin 3
- pentaxin-related gene, rapidly induced by il-1 beta
- pentaxin-related gene, rapidly induced by IL-1 beta, tumor necrosis factor, alpha-induced protein 5
- pentaxin-related protein PTX3
- pentraxin 3, long
- pentraxin-3
- pentraxin-related gene, rapidly induced by IL-1 beta
- pentraxin-related protein PTX3
- TNF alpha-induced protein 5
- TNFAIP5
- TSG-14
- tumor necrosis factor alpha-induced protein 5
- tumor necrosis factor-inducible gene 14 protein
- tumor necrosis factor-inducible protein TSG-14
- tumor necrosis factor, alpha-induced protein 5
- NCBI_Gene: 5806
- UniProtKB: P26022
Human PTX3 Predicted Functions
Enables complement component C1q complex binding activity; identical protein binding activity; and virion binding activity. Involved in innate immune response; modulation by host of viral process; and negative regulation of viral entry into host cell. Located in extracellular space. Implicated in cystic fibrosis and invasive aspergillosis. Biomarker of hepatitis C; invasive aspergillosis; pelvic inflammatory disease; pulmonary aspergilloma; and toxic shock syndrome.
Mouse Ptx3 Target Information
- Target Symbol: Ptx3, pentraxin related gene
- Alias:
- AI607804
- expressed sequence AI607804
- pentraxin 3
- TSG-14
- NCBI_Gene: 19288
Mouse Ptx3 Predicted Functions
Enables (1->3)-beta-D-glucan binding activity. Acts upstream of or within several processes, including opsonization; ovarian cumulus expansion; and positive regulation of nitric oxide biosynthetic process. Located in extracellular matrix. Is expressed in cochlea; cochlea epithelium; inner ear vestibular component; organ of Corti; and stria vascularis. Human ortholog(s) of this gene implicated in cystic fibrosis and invasive aspergillosis. Orthologous to human PTX3 (pentraxin 3).
Rat Ptx3 Target Information
- Target Symbol: Ptx3, pentraxin 3
- Alias:
- LOC689388
- pentraxin 3, long
- pentraxin related
- pentraxin related gene
- pentraxin-related protein PTX3
- similar to Pentraxin-related protein PTX3 precursor (Pentaxin-related protein PTX3) (Tumor necrosis factor-inducible protein TSG-14)
- NCBI_Gene: 689388
- UniProtKB: D3ZT94
Rat Ptx3 Predicted Functions
Predicted to enable several functions, including (1->3)-beta-D-glucan binding activity; complement component C1q complex binding activity; and virion binding activity. Predicted to be involved in innate immune response; modulation by host of viral process; and negative regulation of viral entry into host cell. Predicted to act upstream of or within several processes, including opsonization; ovarian cumulus expansion; and positive regulation of nitric oxide biosynthetic process. Predicted to be located in extracellular matrix. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in cystic fibrosis and invasive aspergillosis. Orthologous to human PTX3 (pentraxin 3).
