HGNC ID: 8800
Target Abstract:
Platelet-derived factor (PDGF) is one of many factors that regulate cell growth and division. Chemically, PDGF is A dimeric glycoprotein formed from two A chains (-AA) or two B chains (-BB) or a combination of AB chains (-AB). In particular, it plays an important role in angiogenesis, the growth of pre-existing blood vessel tissue. Uncontrolled angiogenesis is a characteristic of tumors. Hepatocytes and non-absorbent osteoclasts express PDGF-BB and produce osteoblasts and bones. Platelets, macrophages and mast cells also produce PDGF-BB. At the injured site, PDGF-BB promoted the infiltration of neutrophils and macrophages, played a debridement role, promoted the secretion of new extracellular matrix by fibroblasts, and promoted IGF-1-mediated reepithelialization.
PDGFB Target Infomation Overview
- Target Symbol: PDGFB, platelet derived growth factor subunit B
- Alias: SSV
- Previous Names: SIS
- Alias Names: oncogene SIS; becaplermin; platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog); platelet-derived growth factor beta polypeptide
PDGFB, platelet derived growth factor subunit B Target Infomation by Species
- Human
- Mouse
- Rat
Human PDGFB Target Information
- Target Symbol: PDGFB, platelet derived growth factor subunit B
- Alias:
- becaplermin
- c-sis
- FLJ12858
- IBGC5
- PDGF subunit B
- PDGF-2
- PDGF, B chain
- PDGF2
- platelet-derived growth factor 2
- platelet-derived growth factor B chain
- platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
- platelet-derived growth factor subunit B
- platelet-derived growth factor, B chain
- Platelet-derived growth factor, beta polypeptide (oncogene SIS)
- proto-oncogene c-Sis
- SIS
- SSV
- NCBI_Gene: 5155
- UniProtKB: P01127
Human PDGFB Predicted Functions
Enables several functions, including platelet-derived growth factor binding activity; protein dimerization activity; and receptor ligand activity. Involved in several processes, including positive regulation of cell migration; positive regulation of cell population proliferation; and positive regulation of phosphorylation. Located in cell surface. Implicated in basal ganglia calcification; clear cell renal cell carcinoma; connective tissue cancer (multiple); familial meningioma; and prostatic hypertrophy. Biomarker of several diseases, including Kuhnt-Junius degeneration; bone disease (multiple); clear cell renal cell carcinoma; diabetic retinopathy (multiple); and reproductive organ cancer (multiple).
Mouse Pdgfb Target Information
- Target Symbol: Pdgfb, platelet derived growth factor, B polypeptide
- Alias:
- PDGF-B
- simian sarcoma oncogene
- Sis
- NCBI_Gene: 18591
Mouse Pdgfb Predicted Functions
Predicted to enable several functions, including platelet-derived growth factor binding activity; protein dimerization activity; and receptor ligand activity. Involved in several processes, including metanephric glomerular mesangium development; paracrine signaling; and positive regulation of glomerular filtration. Acts upstream of or within several processes, including animal organ development; nervous system development; and regulation of cell migration. Predicted to be located in several cellular components, including basolateral plasma membrane; dendrite; and neuronal cell body. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; cardiovascular system; extraembryonic component; female reproductive system; and nervous system. Human ortholog(s) of this gene implicated in basal ganglia calcification; clear cell renal cell carcinoma; connective tissue cancer (multiple); familial meningioma; and prostatic hypertrophy. Orthologous to human PDGFB (platelet derived growth factor subunit B).
Rat Pdgfb Target Information
- Target Symbol: Pdgfb, platelet derived growth factor subunit B
- Alias:
- c-sis
- pdgf protein
- PDGF subunit B
- PDGF-2
- platelet derived growth factor-bb
- platelet derived growth factor, B polypeptide
- Platelet-derived growth factor
- platelet-derived growth factor B chain
- platelet-derived growth factor beta polypeptide
- platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
- Platelet-derived growth factor same as Sis (Simian sarcoma viral oncogene homologue c-sis)
- platelet-derived growth factor subunit B
- Platelet-derived growth factor, same as Sis (Simian sarcoma viral oncogene homologue, c-sis)
- SIS
- NCBI_Gene: 24628
Rat Pdgfb Predicted Functions
Enables signaling receptor binding activity. Involved in several processes, including positive regulation of biosynthetic process; positive regulation of cell migration; and response to peptide hormone. Located in several cellular components, including basolateral plasma membrane; dendrite; and neuronal cell body. Used to study asthma; brain infarction; glomerulonephritis; and visual epilepsy. Biomarker of cholestasis; hypertension (multiple); liver cirrhosis; oligohydramnios; and ureteral obstruction. Human ortholog(s) of this gene implicated in basal ganglia calcification; clear cell renal cell carcinoma; connective tissue cancer (multiple); familial meningioma; and prostatic hypertrophy. Orthologous to human PDGFB (platelet derived growth factor subunit B).
