HGNC ID: 6343
Target Abstract:
Stem cell factor (SCF) is a cytokine that binds to the c-Kit receptor and exists as both a transmembrane protein and a soluble protein.SCF promotes mast cell adhesion, migration, proliferation, and survival, as well as the release of histamine and trypsin-like enzymes, the latter two of which are involved in the allergic response.SCF synergizes with various growth factors such as IL-3, IL-6, IL-11, GM-CSF, G-CSF, and Epo. , G-CSF and Epo synergize together to induce myeloid and erythroid colony formation. This cytokine plays an important role in hematopoiesis (blood cell production), spermatogenesis and melanogenesis. Myocardial-specific overexpression of transmembrane SCF promotes stem cell migration, improves cardiac function after myocardial infarction, and animal survival. Mutations in the SCF gene in dogs indicate that this gene is a candidate susceptibility gene for skin cancer.
KITLG Target Infomation Overview
- Target Symbol: KITLG, KIT ligand
- Alias: SCF; SF; Kitl; KL-1; FPH2; SLF; DFNA69
- Previous Names: MGF
- Alias Names: mast cell growth factor; stem cell factor; steel factor; familial progressive hyperpigmentation 2
KITLG, KIT ligand Target Infomation by Species
- Human
- Mouse
- Rat
Human KITLG Target Information
- Target Symbol: KITLG, KIT ligand
- Alias:
- c-Kit ligand
- DCUA
- DFNA69
- DKFZp686F2250
- familial progressive hyperpigmentation 2
- FPH2
- FPHH
- kit-ligand
- Kitl
- KL-1
- mast cell growth factor
- MGF
- SCF
- SF
- SHEP7
- SLF
- steel factor
- stem cell factor
- NCBI_Gene: 4254
- UniProtKB: P21583
Human KITLG Predicted Functions
Predicted to enable cytokine activity and stem cell factor receptor binding activity. Involved in embryonic hemopoiesis; male gonad development; and positive regulation of cell population proliferation. Located in several cellular components, including filopodium; lamellipodium; and plasma membrane. Implicated in autosomal dominant nonsyndromic deafness 69 and familial progressive hyperpigmentation with or without hypopigmentation.
Mouse Kitl Target Information
- Target Symbol: Kitl, kit ligand
- Alias:
- blaze
- blz
- Clo
- cloud gray
- Con
- contrasted
- Gb
- grizzle-belly
- Kitlg
- mast cell growth factor
- Mgf
- SCF
- SF
- Sl
- SLF
- steel
- Steel
- Steel factor
- stem cell factor
- NCBI_Gene: 17311
Mouse Kitl Predicted Functions
Enables cytokine activity and stem cell factor receptor binding activity. Acts upstream of or within several processes, including positive regulation of cell differentiation; positive regulation of cell population proliferation; and positive regulation of protein phosphorylation. Located in extracellular space and plasma membrane. Is integral component of membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 69 and familial progressive hyperpigmentation with or without hypopigmentation. Orthologous to human KITLG (KIT ligand).
Rat Kitlg Target Information
- Target Symbol: Kitlg, KIT ligand
- Alias:
- C-kit ligand
- hematopoietic growth factor KL
- Kitl
- Kl1
- Kl2
- LOC60427
- LOC60428
- mast cell growth factor
- Mgf
- SCF
- steel factor/kit ligand
- stem cell factor
- stem cell factor KL-1
- stem cell factor KL-1 precursor
- stem cell factor KL-2 precursor
- NCBI_Gene: 60427
Rat Kitlg Predicted Functions
Predicted to enable cytokine activity and stem cell factor receptor binding activity. Involved in ovarian follicle development and positive regulation of cell population proliferation. Predicted to be located in several cellular components, including extracellular space; filopodium; and lamellipodium. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 69 and familial progressive hyperpigmentation with or without hypopigmentation. Orthologous to human KITLG (KIT ligand).
