HGNC ID: 2771
Target Abstract:
Complement factor D, also known as D factor, also known as lipase, is a serine protease that is necessary to activate the complement pathway. Factor D is a member of the trypsin family of peptidases, encoded by the CFD gene in humans. Factor D is expressed at high levels in various tissues, including monocytes/macrophages, muscles, sciatic nerves, endometrium, kidneys, and intestines, especially in adipocytes. In patients with renal failure, the concentration of circulating factor D increases. Similarly, in patients with Fanconi syndrome, the proximal tubular function of the kidneys is impaired, and the concentration of D-factor in urine is also at high levels.
CFD Target Infomation Overview
- Target Symbol: CFD, complement factor D
- Gene Groups: Granule associated serine proteases of immune defence; Complement system activation components
- Alias: ADN
- Previous Names: DF; PFD
- Alias Names: adipsin; D component of complement (adipsin); properdin factor D; complement factor D (adipsin)
CFD, complement factor D Target Infomation by Species
- Human
- Mouse
- Rat
Human CFD Target Information
- Target Symbol: CFD, complement factor D
- Alias:
- ADIPSIN
- ADN
- C3 convertase activator
- complement factor D (adipsin)
- complement factor D preproprotein
- D component of complement (adipsin)
- DF
- PFD
- properdin factor D
- NCBI_Gene: 1675
- UniProtKB: P00746
Human CFD Predicted Functions
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in complement activation. Predicted to act upstream of or within several processes, including complement activation, alternative pathway; retina development in camera-type eye; and vascular associated smooth muscle cell differentiation. Located in extracellular exosome. Biomarker of obesity.
Mouse Cfd Target Information
- Target Symbol: Cfd, complement factor D (adipsin)
- Alias:
- adipsin
- Adn
- D component (adipsin) of complement
- DF
- factor D
- NCBI_Gene: 11537
Mouse Cfd Predicted Functions
Predicted to enable endopeptidase activity. Acts upstream of or within several processes, including complement activation, alternative pathway; retina development in camera-type eye; and vascular associated smooth muscle cell differentiation. Located in extracellular space. Is expressed in adipose tissue; brown fat; epididymal fat pad; and white fat. Orthologous to human CFD (complement factor D).
Rat Cfd Target Information
- Target Symbol: Cfd, complement factor D
- Alias:
- adipsin
- Adn
- C3 convertase activator
- complement factor D (adipsin)
- D component of complement (adipsin)
- Df
- endogenous vascular elastase
- EVE
- properdin factor D
- NCBI_Gene: 54249
Rat Cfd Predicted Functions
Enables endopeptidase activity. Involved in Notch signaling pathway. Located in extracellular space. Used to study arthus reaction. Biomarker of obesity. Orthologous to human CFD (complement factor D).
