HGNC ID: 6709
Target Abstract:
Tumor necrosis factor beta (TNF-β), also known as lymphotoxin alpha, is a cytokine secreted by lymphocytes.TNF-β mediates many inflammatory, immunostimulatory, and antiviral responses. During developmental stages, TNF-β is also involved in the formation of secondary lymphoid organs and plays a role in apoptosis. In TNF-β knockout mice, all Peyer’s lymphoid aggregates and lymph nodes failed to develop, demonstrating the importance of TNF-β in immune development.
LTA Target Infomation Overview
- Target Symbol: LTA, lymphotoxin alpha
- Gene Groups: Tumor necrosis factor superfamily
- Alias: TNFSF1; LT
- Previous Names: TNFB
- Alias Names: TNF superfamily member 1; lymphotoxin alpha (TNF superfamily, member 1)
LTA, lymphotoxin alpha Target Infomation by Species
- Human
- Mouse
- Rat
Human LTA Target Information
- Target Symbol: LTA, lymphotoxin alpha
- Alias:
- CDF
- cholinergic differentiation factor
- D factor
- DIA
- differentiation inhibitory activity
- differentiation stimulating factor
- differentiation-inducing factor
- differentiation-stimulating factor
- hepatocyte-stimulating factor III
- HILDA
- human interleukin in DA cells
- leukemia inhibitory factor
- LIF, interleukin 6 family cytokine
- melanoma-derived LPL inhibitor
- MLPLI
- NCBI_Gene: 4049
- UniProtKB: P01374
Human LTA Predicted Functions
Enables cytokine activity; growth factor activity; and leukemia inhibitory factor receptor binding activity. Involved in several processes, including leukemia inhibitory factor signaling pathway; positive regulation of protein modification process; and regulation of epithelial cell differentiation involved in kidney development. Acts upstream of or within several processes, including positive regulation of MAPK cascade; positive regulation of macrophage differentiation; and positive regulation of protein phosphorylation. Located in cytosol.
Mouse Lta Target Information
- Target Symbol: Lta, lymphotoxin A
- Alias:
- heart, lung and blood 382
- hlb382
- LT
- LT-[a]
- LT-alpha
- LT[a]
- LTalpha
- Ltx
- lymphotoxin
- lymphotoxin alpha
- TNF beta
- TNF-beta
- Tnfb
- Tnfsf1b
- tumor necrosis factor beta
- NCBI_Gene: 16992
Mouse Lta Predicted Functions
Predicted to enable tumor necrosis factor receptor binding activity. Acts upstream of or within several processes, including lymph node development; positive regulation of immune response; and positive regulation of interferon-gamma production. Predicted to be located in extracellular space. Is expressed in several structures, including extraembryonic component; gut; hemolymphoid system; liver; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); glucose metabolism disease (multiple); leishmaniasis (multiple); and lung disease (multiple). Orthologous to human LTA (lymphotoxin alpha).
Rat Lta Target Information
- Target Symbol: Lta, lymphotoxin alpha
- Alias:
- LOC103690381
- LT-alpha
- lymphotoxin A
- Lymphotoxin alpha (formerly tumor necrosis factor beta)
- Lymphotoxin alpha (formerly tumor necrosis factor, beta)
- lymphotoxin alpha (TNF superfamily, member 1)
- lymphotoxin-alpha
- lymphotoxin-alpha-like
- TNF-beta
- Tnfb
- tumor necrosis factor beta
- tumor necrosis factor ligand superfamily member 1
- NCBI_Gene: 25008
- UniProtKB: Q06332
Rat Lta Predicted Functions
Predicted to enable cytokine activity and tumor necrosis factor receptor binding activity. Involved in several processes, including negative regulation of fibroblast proliferation; positive regulation of glial cell proliferation; and response to lipopolysaccharide. Located in extracellular space. Biomarker of cystitis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); glucose metabolism disease (multiple); leishmaniasis (multiple); and lung disease (multiple). Orthologous to human LTA (lymphotoxin alpha).
