HGNC ID: 3236
Target Abstract:
Epidermal growth factor receptor (EGFR), also known as ErbB1 and HER1, is a type I transmembrane glycoprotein. It exists on the surface of cells and relies on its specific ligands, including EGF and TGF- α Combine to activate. EGFR signaling plays an important role in regulating cell proliferation, survival, and differentiation. After binding with ligands, EGFR induces homologous or heterodimerization, leading to subsequent tyrosine self phosphorylation and various downstream pathways (MAPK, PI3K/PKB, and STAT). The activation of this receptor plays an important role in the innate immune response of human skin, and overexpression (upregulation) or excessive activity of EGFR is associated with many cancers, including lung cancer, anal cancer, and glioblastoma multiforme. Abnormal EGFR signal is related to psoriasis, eczema and atherosclerosis. At present, researchers believe that EGFR can be a target for cancer treatment.
EGFR Target Infomation Overview
- Target Symbol: EGFR, epidermal growth factor receptor
- Gene Groups: Erb-b2 receptor tyrosine kinases
- Alias: ERBB1; ERRP
- Previous Names: ERBB
- Alias Names: erythroblastic leukemia viral (v-erb-b) oncogene homolog (avian); erb-b2 receptor tyrosine kinase 1; epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)
EGFR, epidermal growth factor receptor Target Infomation by Species
- Human
- Mouse
- Rat
Human EGFR Target Information
- Target Symbol: EGFR, epidermal growth factor receptor
- Alias:
- avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
- cell growth inhibiting protein 40
- cell proliferation-inducing protein 61
- EGFR vIII
- epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
- epidermal growth factor receptor tyrosine kinase domain
- erb-b2 receptor tyrosine kinase 1
- ERBB
- ERBB1
- ERRP
- erythroblastic leukemia viral (v-erb-b) oncogene homolog
- HER1
- mENA
- NISBD2
- PIG61
- proto-oncogene c-ErbB-1
- receptor tyrosine-protein kinase erbB-1
- NCBI_Gene: 1956
- UniProtKB: P00533
Human EGFR Predicted Functions
Enables several functions, including actin filament binding activity; enzyme binding activity; and epidermal growth factor-activated receptor activity. Contributes to nitric-oxide synthase regulator activity. Involved in several processes, including positive regulation of macromolecule metabolic process; regulation of intracellular signal transduction; and regulation of protein metabolic process. Acts upstream of or within epidermal growth factor receptor signaling pathway and positive regulation of cell population proliferation. Located in several cellular components, including basolateral plasma membrane; endosome; and membrane raft. Part of receptor complex. Is active in ruffle membrane. Colocalizes with endosome. Implicated in several diseases, including colorectal cancer; lung non-small cell carcinoma (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Biomarker of several diseases, including Human papillomavirus infectious disease; breast cancer (multiple); carcinoma (multiple); chronic obstructive pulmonary disease; and pulmonary hypertension.
Mouse Egfr Target Information
- Target Symbol: Egfr, epidermal growth factor receptor
- Alias:
- 9030024J15Rik
- AI552599
- avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
- avian erythroblastosis oncogene B
- Erbb
- Errb1
- expressed sequence AI552599
- RIKEN cDNA 9030024J15 gene
- wa-2
- wa2
- Wa5
- waved 2
- waved 5
- NCBI_Gene: 13649
Mouse Egfr Predicted Functions
Enables epidermal growth factor binding activity and epidermal growth factor-activated receptor activity. Involved in cellular response to amino acid stimulus and positive regulation of fibroblast proliferation. Acts upstream of or within several processes, including animal organ development; epidermal growth factor receptor signaling pathway; and protein autophosphorylation. Located in several cellular components, including basolateral plasma membrane; endocytic vesicle; and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; brain; integumental system; limb; and respiratory system. Used to study Coronavirus infectious disease and aortic valve disease. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; lung non-small cell carcinoma (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Orthologous to human EGFR (epidermal growth factor receptor).
Rat Egfr Target Information
- Target Symbol: Egfr, epidermal growth factor receptor
- Alias:
- avian erythroblastic leukemia viral (v-erbB) oncogene homolog
- Egfr-related peptide
- Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1)
- Epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1)
- ErbB-1
- ERBB1
- Errp
- NCBI_Gene: 24329
Rat Egfr Predicted Functions
Enables several functions, including calmodulin binding activity; epidermal growth factor binding activity; and epidermal growth factor-activated receptor activity. Involved in several processes, including animal organ development; neurogenesis; and positive regulation of cell communication. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and cytoplasmic vesicle. Used to study bronchiolo-alveolar adenocarcinoma; dilated cardiomyopathy; and high grade glioma. Biomarker of several diseases, including Parkinsonism; acute kidney failure; lung disease (multiple); median neuropathy; and peptic esophagitis. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; lung non-small cell carcinoma (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Orthologous to human EGFR (epidermal growth factor receptor).
