HGNC ID: 12663
Target Abstract:
Vascular cell adhesion molecule 1 (VCAM-1), also known as CD106, is a 100-110 kDa type I transmembrane protein, usually with seven C2-type immunoglobulin structural domains, that functions as a cell adhesion molecule.The VCAM-1 protein mediates the adhesion to the vascular endothelium of lymphocytes, monocytes, eosinophils, basophils, etc. VCAM-1 is an integral member of the integrins& beta;1 subfamily VLA-4 (very late antigen-4 or α4β1) and endothelial ligands for integrins α4β7. VCAM-1 expression has also been observed on other cell types. It also interacts with EZR and membrane bursting proteins.Other functions of VCAM-1 include the regulation of osteoclastogenesis through cell-cell contacts and the induction of sickle cell adhesion to vascular endothelial cells in response to hypoxia. It also plays a role in leukocyte-endothelial cell signaling. Monitoring serum levels of sVCAM-1 expression may provide a more detailed perspective on a variety of pathologies, such as atherosclerosis and rheumatoid arthritis.
VCAM1 Target Infomation Overview
- Target Symbol: VCAM1, vascular cell adhesion molecule 1
- Gene Groups: CD molecules; Receptor ligands; C2-set domain containing; I-set domain containing; Ig-like cell adhesion molecule family
- Alias: CD106
VCAM1, vascular cell adhesion molecule 1 Target Infomation by Species
- Human
- Mouse
- Rat
Human VCAM1 Target Information
- Target Symbol: VCAM1, vascular cell adhesion molecule 1
- Alias:
- CD106
- CD106 antigen
- DKFZp779G2333
- INCAM-100
- MGC99561
- vascular cell adhesion protein 1
- NCBI_Gene: 7412
- UniProtKB: P19320
Human VCAM1 Predicted Functions
Enables integrin binding activity and primary amine oxidase activity. Involved in several processes, including calcium-mediated signaling using intracellular calcium source; cell-cell adhesion in response to extracellular stimulus; and cellular response to amyloid-beta. Located in several cellular components, including early endosome; external side of plasma membrane; and podosome. Part of alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex. Biomarker of several diseases, including artery disease (multiple); diabetes mellitus (multiple); essential thrombocythemia; glomerulonephritis (multiple); and interstitial cystitis.
Mouse Vcam1 Target Information
- Target Symbol: Vcam1, vascular cell adhesion molecule 1
- Alias:
- CD106
- Vcam-1
- NCBI_Gene: 22329
Mouse Vcam1 Predicted Functions
Predicted to enable integrin binding activity and primary amine oxidase activity. Acts upstream of or within several processes, including cellular response to glucose stimulus; chorio-allantoic fusion; and heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Located in apical plasma membrane. Is expressed in several structures, including brain; embryo mesenchyme; extraembryonic component; heart; and hemolymphoid system. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human VCAM1 (vascular cell adhesion molecule 1).
Rat Vcam1 Target Information
- Target Symbol: Vcam1, vascular cell adhesion molecule 1
- Alias:
- LOC100912479
- MGC108734
- V-CAM 1
- vascular cell adhesion protein 1
- vascular cell adhesion protein 1-like
- VCAM-1
- VCAM1B
- NCBI_Gene: 25361
Rat Vcam1 Predicted Functions
Enables integrin binding activity. Involved in several processes, including cellular response to tumor necrosis factor; nervous system development; and response to lipopolysaccharide. Located in cell surface; extracellular space; and sarcolemma. Used to study carotid stenosis and hypertension. Biomarker of several diseases, including artery disease (multiple); chronic kidney disease; colitis; periodontitis; and thromboangiitis obliterans. Orthologous to human VCAM1 (vascular cell adhesion molecule 1).
