Granulomatous protein (GRN) is encoded by the GRN gene in humans. Its precursor protein, granulin precursor, is also known as teratoma cell-derived growth factor. The signaling peptide is sheared to produce mature GRN, and further shearing produces many active peptides with a molecular weight of 6 kDa. Both peptides and intact GRN regulate cell growth. However, different members of the GRN family of proteins may have inhibitory and/or promotional effects on cell growth.Members of the GRN family have important roles in normal development, wound healing, and tumorigenesis.GRN may have cytokine-like activity and may play a role in inflammation, wound repair, and tissue remodeling. Human liver flukes secrete GRN-like growth hormones that contribute to the development of cholangiocarcinoma.Mutations in the GRN gene can be inherited through autosomal dominant inheritance with high epistasis, producing up to 25% frontotemporal lobar degeneration.