HGNC ID: 4601
Target Abstract:
Granulomatous protein (GRN) is encoded by the GRN gene in humans. Its precursor protein, granulin precursor, is also known as teratoma cell-derived growth factor. The signaling peptide is sheared to produce mature GRN, and further shearing produces many active peptides with a molecular weight of 6 kDa. Both peptides and intact GRN regulate cell growth. However, different members of the GRN family of proteins may have inhibitory and/or promotional effects on cell growth.Members of the GRN family have important roles in normal development, wound healing, and tumorigenesis.GRN may have cytokine-like activity and may play a role in inflammation, wound repair, and tissue remodeling. Human liver flukes secrete GRN-like growth hormones that contribute to the development of cholangiocarcinoma.Mutations in the GRN gene can be inherited through autosomal dominant inheritance with high epistasis, producing up to 25% frontotemporal lobar degeneration.
GRN Target Infomation Overview
- Target Symbol: GRN, granulin precursor
- Alias: PCDGF; PGRN; CLN11
- Alias Names: progranulin
GRN, granulin precursor Target Infomation by Species
- Human
- Mouse
- Rat
Human GRN Target Information
- Target Symbol: GRN, granulin precursor
- Alias:
- acrogranin
- CLN11
- epithelin
- GEP
- glycoprotein 88
- glycoprotein of 88 Kda
- GP88
- granulin
- granulin-epithelin
- granulins
- PC cell-derived growth factor
- PCDGF
- PEPI
- PGRN
- proepithelin
- progranulin
- NCBI_Gene: 2896
- UniProtKB: P28799
Human GRN Predicted Functions
Enables chaperone binding activity. Involved in several processes, including lysosomal lumen acidification; negative regulation of respiratory burst involved in inflammatory response; and positive regulation of lysosome organization. Located in several cellular components, including Golgi apparatus; late endosome; and lysosomal membrane. Implicated in dementia (multiple); neurodegenerative disease (multiple); neuronal ceroid lipofuscinosis 11; and primary progressive multiple sclerosis. Biomarker of several diseases, including Grn-related frontotemporal lobar degeneration with Tdp43 inclusions; atherosclerosis; autistic disorder; multiple sclerosis (multiple); and neurodegenerative disease (multiple).
Mouse Grn Target Information
- Target Symbol: Grn, granulin
- Alias:
- acrogranulin
- epithelin
- PC cell-derived growth factor
- Pgrn
- progranulin
- NCBI_Gene: 14824
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- UniprotKB: P28798
- UniprotKB: H3BJ90
- UniprotKB: H3BJE0
- UniprotKB: H3BLC9
- UniprotKB: Q3TVQ3
- UniprotKB: Q3TW77
- UniprotKB: Q3TWT4
- UniprotKB: Q3TX66
- UniprotKB: Q3U5Q6
- UniprotKB: Q3U8W3
- UniprotKB: Q3U9K2
- UniprotKB: Q3U9N4
- UniprotKB: Q3UAJ3
- UniprotKB: Q3UC19
- UniprotKB: Q3UD85
- UniprotKB: Q3UDD6
- UniprotKB: Q544Y8
Mouse Grn Predicted Functions
Predicted to enable chaperone binding activity. Involved in several processes, including astrocyte activation involved in immune response; positive regulation of cellular component organization; and regulation of defense response. Acts upstream of or within several processes, including blastocyst hatching; locomotory exploration behavior; and lysosomal protein catabolic process. Located in several cellular components, including endoplasmic reticulum; lysosome; and trans-Golgi network. Is expressed in several structures, including early conceptus; gonad; integument; nervous system; and placenta. Used to study Grn-related frontotemporal lobar degeneration with Tdp43 inclusions and nephrogenic diabetes insipidus. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); neuronal ceroid lipofuscinosis 11; and primary progressive multiple sclerosis. Orthologous to human GRN (granulin precursor).
Rat Grn Target Information
- Target Symbol: Grn, granulin precursor
- Alias:
- acrogranin
- epithelin
- granulin
- granulins
- PEPI
- PGRN
- proepithelin
- progranulin
- prostate cancer cell-derived growth factor
- NCBI_Gene: 29143
Rat Grn Predicted Functions
Predicted to enable chaperone binding activity. Involved in several processes, including chondrocyte proliferation; positive regulation of dendritic spine development; and response to estradiol. Predicted to be located in several cellular components, including late endosome; lysosomal membrane; and trans-Golgi network. Predicted to be active in extracellular region. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); neuronal ceroid lipofuscinosis 11; and primary progressive multiple sclerosis. Orthologous to human GRN (granulin precursor).
