HGNC ID: 6106
Target Abstract:
FoxP3 protein, a member of the forkhead family of transcription factors, is expressed in regulatory T cells (Treg), whose development and function are affected by forkhead proteins.Aberrant expression of FoxP3 in T cells inhibits their activity and cytokine secretion.
FOXP3 Target Infomation Overview
- Target Symbol: FOXP3, forkhead box P3
- Gene Groups: Forkhead boxes
- Alias: JM2; XPID; AIID; PIDX; DIETER; SCURFIN
- Previous Names: IPEX
- Alias Names: immune dysregulation, polyendocrinopathy, enteropathy, X-linked
FOXP3, forkhead box P3 Target Infomation by Species
- Human
- Mouse
- Rat
Human FOXP3 Target Information
- Target Symbol: FOXP3, forkhead box P3
- Alias:
- AIID
- DIETER
- forkhead box protein P3
- FOXP3delta7
- immune dysregulation, polyendocrinopathy, enteropathy, X-linked
- immunodeficiency, polyendocrinopathy, enteropathy, X-linked
- IPEX
- JM2
- MGC141961
- MGC141963
- PIDX
- scurfin
- XPID
- NCBI_Gene: 50943
- UniProtKB: Q9BZS1
Human FOXP3 Predicted Functions
Enables several functions, including NFAT protein binding activity; enzyme binding activity; and protein homodimerization activity. Involved in several processes, including negative regulation of T cell activation; regulation of gene expression; and regulation of histone modification. Located in cytoplasm and nucleoplasm. Implicated in Human papillomavirus infectious disease; colorectal cancer; immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome; pulmonary tuberculosis; and type 1 diabetes mellitus. Biomarker of several diseases, including adult T-cell leukemia; anogenital venereal wart; chlamydia; liver disease (multiple); and tuberculosis (multiple).
Mouse Foxp3 Target Information
- Target Symbol: Foxp3, forkhead box P3
- Alias:
- JM2
- scurfin
- scurfy
- sf
- NCBI_Gene: 20371
Mouse Foxp3 Predicted Functions
Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding activity; and transcription corepressor activity. Involved in negative regulation of interferon-gamma production; negative regulation of interleukin-17 production; and regulation of T cell anergy. Acts upstream of or within several processes, including positive regulation of T cell tolerance induction; regulation of T cell activation; and regulation of gene expression. Located in cytoplasm and nucleus. Is expressed in central nervous system; genitourinary system; hemolymphoid system; and retina. Used to study Wiskott-Aldrich syndrome and immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome. Human ortholog(s) of this gene implicated in Human papillomavirus infectious disease; colorectal cancer; immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome; pulmonary tuberculosis; and type 1 diabetes mellitus. Orthologous to human FOXP3 (forkhead box P3).
Rat Foxp3 Target Information
- Target Symbol: Foxp3, forkhead box P3
- Alias:
- forkhead box protein P3
- LOC317382
- RGD1562112
- similar to scurfin
- NCBI_Gene: 317382
Rat Foxp3 Predicted Functions
Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; NFAT protein binding activity; and enzyme binding activity. Involved in several processes, including establishment of endothelial blood-brain barrier; negative regulation of defense response to virus; and response to rapamycin. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Used to study intrahepatic cholangiocarcinoma. Biomarker of Korean hemorrhagic fever; asthma; bronchiolitis obliterans; hypertension; and hypothyroidism. Human ortholog(s) of this gene implicated in Human papillomavirus infectious disease; colorectal cancer; immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome; pulmonary tuberculosis; and type 1 diabetes mellitus. Orthologous to human FOXP3 (forkhead box P3).