HGNC ID: 13916
Target Abstract:
Apolipoprotein M (Apo M) is encoded by the APOM gene in humans. The protein encoded by this gene is an apolipoprotein and is a member of the Apo family of proteins. Apo M has been found to be associated with high-density lipoproteins and, to a lesser extent, with low-density lipoproteins and triglyceride-rich lipoproteins.Apo M is secreted through the plasma membrane but remains bound to the membrane and is involved in lipid transport. The APOM gene was found to have 2 transcript variants encoding 2 different isoforms, but only one of them was fully characterized.The average molecular weight of Apo M is 21,253 Da, and the molecular weight of the single isoform is 21,239 Da.
APOM Target Infomation Overview
- Target Symbol: APOM, apolipoprotein M
- Gene Groups: Apolipoproteins; Lipocalins
- Alias: G3a; NG20
APOM, apolipoprotein M Target Infomation by Species
- Human
- Mouse
- Rat
Human APOM Target Information
- Target Symbol: APOM, apolipoprotein M
- Alias:
- alternative name: G3a, NG20
- apo-M
- G3a
- HSPC336
- MGC22400
- NG20
- NG20-like protein
- NCBI_Gene: 55937
- UniProtKB: O95445
Human APOM Predicted Functions
Enables antioxidant activity; lipid transporter activity; and phospholipid binding activity. Involved in cholesterol efflux; high-density lipoprotein particle remodeling; and negative regulation of plasma lipoprotein oxidation. Part of high-density lipoprotein particle; low-density lipoprotein particle; and very-low-density lipoprotein particle. Implicated in coronary artery disease; type 1 diabetes mellitus; and type 2 diabetes mellitus.
Mouse Apom Target Information
- Target Symbol: Apom, apolipoprotein M
- Alias:
- 1190010O19Rik
- G3a
- NG20
- RIKEN cDNA 1190010O19 gene
- NCBI_Gene: 55938
Mouse Apom Predicted Functions
Enables antioxidant activity. Involved in several processes, including cholesterol efflux; high-density lipoprotein particle clearance; and plasma lipoprotein particle organization. Acts upstream of or within lipoprotein metabolic process and reverse cholesterol transport. Located in extracellular region. Part of discoidal high-density lipoprotein particle. Is expressed in several structures, including gut; liver; male reproductive gland or organ; and urinary system. Human ortholog(s) of this gene implicated in coronary artery disease; type 1 diabetes mellitus; and type 2 diabetes mellitus. Orthologous to human APOM (apolipoprotein M).
Rat Apom Target Information
- Target Symbol: Apom, apolipoprotein M
- Alias:
- apo-M
- protein Px
- NCBI_Gene: 55939
- UniProtKB: P14630
Rat Apom Predicted Functions
Predicted to enable antioxidant activity; lipid transporter activity; and phospholipid binding activity. Involved in response to glucose. Located in extracellular space. Human ortholog(s) of this gene implicated in coronary artery disease; type 1 diabetes mellitus; and type 2 diabetes mellitus. Orthologous to human APOM (apolipoprotein M).
