HGNC ID: 7175
Target Abstract:
Matrix metalloproteinase 8 (MMP-8), also known as neutrophil collagenase or PMNL collagenase, is a collagen lyase present in the connective tissues of most mammals. In humans, the MMP-8 protein is encoded by the MMP8 gene. A variety of substances, such as IL-1, IL-8, TNF-α, and GM-CSF, stimulate neutroneuter cells to release MMP-8, a key enzyme that initiates ECM breakdown. Activated MMP-8 can cleat natural proteins such as fibronectin, chondroproteoglycan, serine protease inhibitor protein, and polypeptides. MMP-8 affects the metastatic behavior of breast cancer cells by preventing lymph node metastasis, emphasizing the importance of anti-target recognition in drug development. MMP-8 is involved in wound repair by eliminating inflammation, which provides a certain possibility for the development of new strategies for the treatment of poor wound healing.
MMP8 Target Infomation Overview
- Target Symbol: MMP8, matrix metallopeptidase 8
- Gene Groups: M10 matrix metallopeptidases
- Previous Names: CLG1
- Alias Names: matrix metalloproteinase 8 (neutrophil collagenase)
MMP8, matrix metallopeptidase 8 Target Infomation by Species
- Human
- Mouse
- Rat
Human MMP8 Target Information
- Target Symbol: MMP8, matrix metallopeptidase 8
- Alias:
- CLG1
- collagenase 2
- HNC
- matrix metalloproteinase 8 (neutrophil collagenase)
- matrix metalloproteinase-8
- MMP-8
- neutrophil collagenase
- PMN leukocyte collagenase
- PMNL collagenase
- PMNL-CL
- NCBI_Gene: 4317
- UniProtKB: P22894
Human MMP8 Predicted Functions
Enables serine-type endopeptidase activity. Involved in endodermal cell differentiation and proteolysis. Located in extracellular space. Implicated in breast cancer and carotid artery disease. Biomarker of COVID-19; aortic aneurysm (multiple); arthritis (multiple); breast cancer; and female reproductive organ cancer (multiple).
Mouse Mmp8 Target Information
- Target Symbol: Mmp8, matrix metallopeptidase 8
- Alias:
- BB138268
- Collagenase-2
- expressed sequence BB138268
- NCBI_Gene: 17394
Mouse Mmp8 Predicted Functions
Predicted to enable endopeptidase activity and metal ion binding activity. Involved in several processes, including positive regulation of biosynthetic process; positive regulation of intracellular signal transduction; and regulation of cytokine production. Located in extracellular space. Is expressed in several structures, including central nervous system; genitourinary system; hindlimb digit mesenchyme; musculature; and skeleton. Human ortholog(s) of this gene implicated in breast cancer and carotid artery disease. Orthologous to human MMP8 (matrix metallopeptidase 8).
Rat Mmp8 Target Information
- Target Symbol: Mmp8, matrix metallopeptidase 8
- Alias:
- matrix metalloproteinase-8
- MMP-8
- neutrophil collagenase
- neutrophil collagenease
- NCBI_Gene: 63849
Rat Mmp8 Predicted Functions
Enables calcium ion binding activity; metallopeptidase activity; and zinc ion binding activity. Involved in several processes, including positive regulation of neuroinflammatory response; positive regulation of nitric oxide biosynthetic process; and positive regulation of tumor necrosis factor production. Located in extracellular space. Biomarker of congestive heart failure. Human ortholog(s) of this gene implicated in breast cancer and carotid artery disease. Orthologous to human MMP8 (matrix metallopeptidase 8).
