HGNC ID: 4187
Target Abstract:
Vitamin D binding protein (VitaminDBP), also known as GC (group specific component) globulin, belongs to the albumin gene family along with human serum albumin and alpha fetoprotein. It has multiple functions and exists on the surface of plasma, ascites, cerebrospinal fluid, and many types of cells. It binds to vitamin D and its metabolites, transporting them to target tissues. As a macrophage activating factor derived from Gc protein, VitaminDBP can be used for cancer treatment to activate macrophages to resist tumor cells.
GC Target Infomation Overview
- Target Symbol: GC, GC vitamin D binding protein
- Alias: DBP; VDBP; hDBP
- Alias Names: group-specific component (vitamin D binding protein); GC, vitamin D binding protein
GC, GC vitamin D binding protein Target Infomation by Species
- Human
- Mouse
- Rat
Human GC Target Information
- Target Symbol: GC, GC vitamin D binding protein
- Alias:
- DBP
- DBP-maf
- DBP/GC
- epididymis secretory protein Li 51
- gc protein-derived macrophage activating factor
- gc-globulin
- Gc-MAF
- GcMAF
- GRD3
- group-specific component (vitamin D binding protein)
- HEL-S-51
- VDB
- VDBG
- VDBP
- vitamin D-binding alpha-globulin
- vitamin D-binding protein
- vitamin D-binding protein-macrophage activating factor
- NCBI_Gene: 2638
- UniProtKB: P02774
Human GC Predicted Functions
Enables actin binding activity and calcidiol binding activity. Predicted to be involved in vitamin transport. Predicted to act upstream of or within vitamin D metabolic process. Located in blood microparticle and extracellular exosome. Implicated in several diseases, including autoimmune disease (multiple); chronic obstructive pulmonary disease; hepatocellular carcinoma; human immunodeficiency virus infectious disease; and rheumatic fever. Biomarker of several diseases, including autoimmune disease (multiple); dengue disease; diabetic retinopathy; hepatic encephalopathy; and sciatic neuropathy.
Mouse Gc Target Information
- Target Symbol: Gc, vitamin D binding protein
- Alias:
- DBP
- NCBI_Gene: 14473
Mouse Gc Predicted Functions
Predicted to enable actin binding activity and calcidiol binding activity. Acts upstream of or within vitamin D metabolic process. Predicted to be located in several cellular components, including axon; extracellular space; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including gut; hemolymphoid system gland; liver; male reproductive gland or organ; and trigeminal nerve. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); chronic obstructive pulmonary disease; hepatocellular carcinoma; human immunodeficiency virus infectious disease; and rheumatic fever. Orthologous to human GC (GC vitamin D binding protein).
Rat Gc Target Information
- Target Symbol: Gc, GC, vitamin D binding protein
- Alias:
- DBP
- DBP02
- gc-globulin
- group specific component
- group-specific component
- Group-specific component (vitamin D-binding protein)
- RATDBP02
- VDB
- Vdbp
- vitamin D-binding protein
- NCBI_Gene: 24384
Rat Gc Predicted Functions
Enables vitamin D binding activity. Involved in several processes, including female pregnancy; lactation; and response to estradiol. Located in several cellular components, including axon; extracellular space; and perinuclear region of cytoplasm. Biomarker of brain ischemia and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); chronic obstructive pulmonary disease; hepatocellular carcinoma; human immunodeficiency virus infectious disease; and rheumatic fever. Orthologous to human GC (GC vitamin D binding protein).
