HGNC ID: 7997
Target Abstract:
Neuregulin 1 (NRG1) was originally identified as a 44 kD glycoprotein that interacts with NEU/ERBB2 receptor tyrosine kinase to increase the phosphorylation of tyrosine residues. A variety of different isomers are produced from NRG1 gene by alternative splicing. These subtypes include heregulins (HRGs), nerve growth factors (GGFS), and sensory and motor neuron-derived factors (SMDF). Neuregulin and its various subtypes are derived from a family of four structurally related proteins that are part of the EGF protein family. These proteins play multiple roles not only in nervous system development but also in vertebrate embryonic development, including heart development, neurembrane and oligodendrocyte differentiation, some aspects of neural development, and the formation of neuromuscular synapses.
NRG1 Target Infomation Overview
- Target Symbol: NRG1, neuregulin 1
- Gene Groups: I-set domain containing; Neuregulins
- Alias: HRG; NDF; GGF
- Previous Names: HGL; NRG1-IT2
- Alias Names: NRG1 intronic transcript 2 (non-protein coding)
NRG1, neuregulin 1 Target Infomation by Species
- Human
- Mouse
- Rat
Human NRG1 Target Information
- Target Symbol: NRG1, neuregulin 1
- Alias:
- acetylcholine receptor-inducing activity
- ARIA
- GGF
- GGF2
- glial growth factor
- glial growth factor 2
- heregulin, alpha (45kD, ERBB2 p185-activator)
- HGL
- HRG
- HRG1
- HRGA
- MST131
- MSTP131
- NDF
- neu differentiation factor
- neuregulin 1 type IV beta 1a
- neuregulin 1 type IV beta 3
- NRG1 intronic transcript 2 (non-protein coding)
- NRG1-IT2
- pro-neuregulin-1, membrane-bound isoform
- pro-NRG1
- sensory and motor neuron derived factor
- SMDF
- NCBI_Gene: 3084
- UniProtKB: Q02297
Human NRG1 Predicted Functions
Enables protein tyrosine kinase activator activity; signaling receptor binding activity; and transcription coregulator activity. Involved in several processes, including ERBB signaling pathway; heart development; and positive regulation of protein phosphorylation. Acts upstream of or within cellular protein complex disassembly and negative regulation of transcription, DNA-templated. Located in apical plasma membrane; extracellular space; and nucleoplasm. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane and integral component of presynaptic active zone membrane. Implicated in several diseases, including bipolar disorder; cerebral malaria; dementia; middle cerebral artery infarction; and psychotic disorder (multiple). Biomarker of Alzheimer’s disease; hepatocellular carcinoma; major depressive disorder; and ovarian cancer.
Mouse Nrg1 Target Information
- Target Symbol: Nrg1, neuregulin 1
- Alias:
- 6030402G23Rik
- ARIA
- D230005F13Rik
- GGF
- GGFII
- heregulin
- Hgl
- HGL
- HRG
- HRGalpha
- NDF
- RIKEN cDNA 6030402G23 gene
- RIKEN cDNA D230005F13 gene
- SMDF
- NCBI_Gene: 211323
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- UniprotKB: A0A140LHD8
- UniprotKB: A0A140LHG5
- UniprotKB: A0A140LHN1
- UniprotKB: A0A140LHQ6
- UniprotKB: A0A140LHZ9
- UniprotKB: A0A140LIG9
- UniprotKB: A0A140LIJ3
- UniprotKB: A0A140LIK5
- UniprotKB: A0A140LIP8
- UniprotKB: A0A140LJ88
- UniprotKB: A0A140LJC1
- UniprotKB: A0A5F8MP73
- UniprotKB: A0A5F8MPA3
- UniprotKB: A0A5F8MPD1
- UniprotKB: A0A5F8MPJ0
- UniprotKB: A0A5F8MPL7
- UniprotKB: A0A5F8MPM6
- UniprotKB: A0A5F8MPT0
- UniprotKB: A0A5F8MPT8
- UniprotKB: A0A5F8MPU1
- UniprotKB: A0A5F8MPU8
- UniprotKB: A0A5F8MQ03
- UniprotKB: A0A5F8MQ49
- UniprotKB: Q3TD94
- UniprotKB: Q3URY7
- UniprotKB: Q6DR98
- UniprotKB: Q6DR99
- UniprotKB: Q810X0
- UniprotKB: Q8BX76
Mouse Nrg1 Predicted Functions
Enables ErbB-2 class receptor binding activity and chemorepellent activity. Involved in several processes, including positive regulation of cardiac muscle cell differentiation; postsynapse to nucleus signaling pathway; and synapse assembly. Acts upstream of or within several processes, including neurogenesis; positive regulation of intracellular signal transduction; and positive regulation of macromolecule metabolic process. Located in several cellular components, including axolemma; external side of plasma membrane; and neuromuscular junction. Is integral component of plasma membrane. Is active in GABA-ergic synapse and glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Used to study schizophrenia. Human ortholog(s) of this gene implicated in several diseases, including bipolar disorder; cerebral malaria; dementia; middle cerebral artery infarction; and psychotic disorder (multiple). Orthologous to human NRG1 (neuregulin 1).
Rat Nrg1 Target Information
- Target Symbol: Nrg1, neuregulin 1
- Alias:
- glial growth factor
- neuregulin 1 type III beta 3
- pro-neuregulin-1, membrane-bound isoform
- pro-NRG1
- NCBI_Gene: 112400
-
- UniprotKB: A0A0G2K057
- UniprotKB: A0A0G2K3Q3
- UniprotKB: D3ZC94
- UniprotKB: D4ACB2
- UniprotKB: G3V7D6
- UniprotKB: G3V7F0
- UniprotKB: G3V9Q0
- UniprotKB: P43322
- UniprotKB: Q3S2T6
- UniprotKB: Q52R82
- UniprotKB: Q9ESA1
- UniprotKB: Q9ESA2
- UniprotKB: Q9ESA3
- UniprotKB: Q9ESA4
- UniprotKB: Q9ESA5
- UniprotKB: Q9ESA6
- UniprotKB: Q9ESA7
- UniprotKB: Q9ESA8
- UniprotKB: Q9ESA9
- UniprotKB: Q9ESB0
- UniprotKB: Q9ESB1
Rat Nrg1 Predicted Functions
Enables receptor tyrosine kinase binding activity. Involved in several processes, including negative regulation of corticosterone secretion; positive regulation of Schwann cell proliferation; and response to progesterone. Located in extracellular space and synapse. Used to study sciatic neuropathy. Biomarker of diabetic neuropathy; median neuropathy; schizophrenia; and visual epilepsy. Human ortholog(s) of this gene implicated in several diseases, including bipolar disorder; cerebral malaria; dementia; middle cerebral artery infarction; and psychotic disorder (multiple). Orthologous to human NRG1 (neuregulin 1).
