HGNC ID: 9833
Target Abstract:
The receptor for advanced glycosylation end products (RAGE) is a 35 kDa immunoglobulin superfamily transmembrane receptor that derives its name from the ability to bind to advanced glycosylation end products. Given its inflammatory function in innate immunity and its ability to recognize a class of ligands through a common motif, RAGE is often considered a class I recognition receptor.RAGE has been associated with a number of chronic diseases such as atherosclerosis, peripheral vascular disease, myocardial infarction, congestive heart failure, diabetes mellitus, and Alzheimer’s disease. Compared with other tissues, RAGE is most highly expressed in the lungs, especially in type I alveolar epithelial cells, and not in idiopathic pulmonary fibrosis (IPF), suggesting that RAGE is differently expressed and regulated in the pulmonary lineage than in the cardiovascular system. Blockade/knockdown of RAGE results in impaired cell adhesion and increased cell proliferation and migration.
MOK Target Infomation Overview
- Target Symbol: MOK, MOK protein kinase
- Alias: RAGE1; STK30
- Previous Names: RAGE
- Alias Names: renal tumor antigen
MOK, MOK protein kinase Target Infomation by Species
- Human
- Mouse
- Rat
Human MOK Target Information
- Target Symbol: MOK, MOK protein kinase
- Alias:
- MAPK/MAK/MRK overlapping kinase
- RAGE
- RAGE-1
- RAGE1
- renal cell carcinoma antigen
- renal cell carcinoma antigen (MOK protein kinase)
- renal tumor antigen 1
- STK30
- NCBI_Gene: 5891
- UniProtKB: Q9UQ07
Human MOK Predicted Functions
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to be located in ciliary base. Predicted to be active in cytoplasm and nucleus. Biomarker of renal cell carcinoma.
Mouse Mok Target Information
- Target Symbol: Mok, MOK protein kinase
- Alias:
- MAPK/MAK/MRK/ overlapping kinase
- MOK
- Rage
- renal tumor antigen
- serine/threonine kinase 30
- Stk30
- NCBI_Gene: 26448
Mouse Mok Predicted Functions
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within phosphorylation. Located in ciliary base and nucleus. Is expressed in gonad. Orthologous to human MOK (MOK protein kinase).
Rat Mok Target Information
- Target Symbol: Mok, MOK protein kinase
- Alias:
- LOC362787
- MAPK/MAK/MRK overlapping kinase
- MGC94988
- Rage
- renal tumor antigen
- NCBI_Gene: 362787
Rat Mok Predicted Functions
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to be located in ciliary base. Predicted to be active in cytoplasm and nucleus. Orthologous to human MOK (MOK protein kinase).
