HGNC ID: 13633
Target Abstract:
Lipocalin, also known as adipocyte complement-related protein 30 (Acrp30), is involved in the regulation of glucose levels and fatty acid catabolism. It assembles into different complexes including trimeric, hexameric, and higher order oligomeric structures, which in turn may affect biological activity. Lipocalin is a protein hormone that regulates many metabolic processes including glucose regulation and fatty acid oxidation. Adipose tissue (as well as the placenta during pregnancy) specializes in secreting lipocalin into the blood, and thus plasma is rich in lipocalin relative to many other hormones. Lipocalins may have anti-atherosclerotic and anti-inflammatory effects, and may negatively regulate granulosa progenitor cell growth and TNF-α production in macrophages. Monitoring serum lipocalin levels in a number of pathologies, such as type 2 diabetes mellitus, obesity, atherosclerosis, and nonalcoholic fatty liver disease, may provide more detailed insights into our understanding of lipocalins.
ADIPOQ Target Infomation Overview
- Target Symbol: ADIPOQ, adiponectin, C1Q and collagen domain containing
- Gene Groups: C1q and TNF related
- Alias: ACRP30; apM1; GBP28; adiponectin
- Previous Names: ACDC
- Alias Names: adipose most abundant gene transcript 1; adiponectin precursor; adipocyte, C1Q and collagen domain containing
ADIPOQ, adiponectin, C1Q and collagen domain containing Target Infomation by Species
- Human
- Mouse
- Rat
Human ADIPOQ Target Information
- Target Symbol: ADIPOQ, adiponectin, C1Q and collagen domain containing
- Alias:
- 30 kDa adipocyte complement-related protein
- ACDC
- ACRP30
- adipocyte complement-related 30 kDa protein
- adiponectin
- adipose most abundant gene transcript 1 protein
- adipose specific collagen-like factor
- ADIPQTL1
- ADPN
- APM-1
- APM1
- GBP28
- gelatin-binding protein 28
- NCBI_Gene: 9370
- UniProtKB: Q15848
Human ADIPOQ Predicted Functions
Enables hormone activity; protein homodimerization activity; and sialic acid binding activity. Involved in several processes, including negative regulation of cell communication; negative regulation of cell differentiation; and negative regulation of macromolecule metabolic process. Located in cell surface and extracellular space. Part of collagen-containing extracellular matrix. Implicated in several diseases, including carcinoma (multiple); cardiovascular system disease (multiple); non-alcoholic fatty liver disease; primary open angle glaucoma; and type 2 diabetes mellitus. Biomarker of several diseases, including autoimmune disease (multiple); cardiovascular system disease (multiple); diabetes mellitus (multiple); fatty liver disease (multiple); and inflammatory bowel disease (multiple).
Mouse Adipoq Target Information
- Target Symbol: Adipoq, adiponectin, C1Q and collagen domain containing
- Alias:
- Acdc
- Acrp30
- Ad
- adipo
- adipocyte complement related protein
- adipocyte, C1Q and collagen domain containing
- adiponectin
- apM1
- APN
- GBP28
- NCBI_Gene: 11450
Mouse Adipoq Predicted Functions
Enables hormone activity and identical protein binding activity. Involved in several processes, including detection of oxidative stress; negative regulation of cold-induced thermogenesis; and regulation of protein serine/threonine kinase activity. Acts upstream of or within with a positive effect on gene expression. Acts upstream of or within several processes, including brown fat cell differentiation; negative regulation of gluconeogenesis; and positive regulation of glucose import. Located in endoplasmic reticulum and extracellular space. Is expressed in several structures, including adipose tissue; axial musculature; gut; male reproductive gland or organ; and serum. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); cardiovascular system disease (multiple); non-alcoholic fatty liver disease; primary open angle glaucoma; and type 2 diabetes mellitus. Orthologous to human ADIPOQ (adiponectin, C1Q and collagen domain containing).
Rat Adipoq Target Information
- Target Symbol: Adipoq, adiponectin, C1Q and collagen domain containing
- Alias:
- Acdc
- Acrp30
- Adid
- adipocyte complement related protein of 30 kDa
- adiponectin
- adiponectin d
- NCBI_Gene: 246253
Rat Adipoq Predicted Functions
Enables identical protein binding activity. Involved in several processes, including cellular response to organonitrogen compound; positive regulation of glycogen (starch) synthase activity; and positive regulation of protein phosphorylation. Located in extracellular space. Part of protein-containing complex. Used to study brain infarction. Biomarker of several diseases, including end stage renal disease; fatty liver disease (multiple); glucose metabolism disease (multiple); hyperthyroidism; and obesity. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); cardiovascular system disease (multiple); non-alcoholic fatty liver disease; primary open angle glaucoma; and type 2 diabetes mellitus. Orthologous to human ADIPOQ (adiponectin, C1Q and collagen domain containing).
