HGNC ID: 11931
Target Abstract:
Tumor necrosis factor-like ligand 1A (TL1A), also known as TNFSF15, is a member of the TNF superfamily. It is a homologous trimer factor consisting of 251 amino acids expressed by the TNFSF15 gene at locus 9q32 on chromosome 9. The expression of this protein is induced by TNF and IL-1α, and it is expressed in large quantities in endothelial cells, but not in B or T cells. This cytokine is a ligand for the TNFRSF25 receptor and the TNFRSF21/DR6 trap receptor. It can activate NF-kappaB and MAP kinase, and can induce apoptosis of vascular endothelial cells as an autocrine factor. This cytokine also inhibits endothelial cell proliferation and thus may act as an angiogenesis inhibitor.
TNFSF15 Target Infomation Overview
- Target Symbol: TNFSF15, TNF superfamily member 15
- Gene Groups: Tumor necrosis factor superfamily
- Alias: TL1; VEGI; TL1A; VEGI192A; MGC129934; MGC129935
- Alias Names: vascular endothelial cell growth inhibitor; TNF superfamily ligand TL1A; TNF ligand-related molecule 1; vascular endothelial growth inhibitor-192A; tumor necrosis factor (ligand) superfamily, member 15
TNFSF15, TNF superfamily member 15 Target Infomation by Species
- Human
- Mouse
- Rat
Human TNFSF15 Target Information
- Target Symbol: TNFSF15, TNF superfamily member 15
- Alias:
- MGC129934
- MGC129935
- TL1
- TL1A
- TNF ligand-related molecule 1
- TNF superfamily ligand TL1A
- TNLG1B
- tumor necrosis factor (ligand) superfamily member 15
- tumor necrosis factor (ligand) superfamily, member 15
- tumor necrosis factor ligand 1B
- tumor necrosis factor ligand superfamily member 15
- tumor necrosis factor superfamily member 15
- vascular endothelial cell growth inhibitor
- vascular endothelial growth inhibitor-192A
- VEGI
- VEGI192A
- NCBI_Gene: 9966
- UniProtKB: O95150
Human TNFSF15 Predicted Functions
Predicted to enable signaling receptor binding activity. Acts upstream of or within activation of NF-kappaB-inducing kinase activity and activation of cysteine-type endopeptidase activity involved in apoptotic process. Located in plasma membrane.
Mouse Tnfsf15 Target Information
- Target Symbol: Tnfsf15, tumor necrosis factor (ligand) superfamily, member 15
- Alias:
- TL1
- TL1A
- VEGI
- NCBI_Gene: 326623
Mouse Tnfsf15 Predicted Functions
Predicted to enable death receptor binding activity. Predicted to be involved in activation of cysteine-type endopeptidase activity involved in apoptotic process and positive regulation of cytokine production. Predicted to act upstream of or within activation of NF-kappaB-inducing kinase activity. Predicted to be located in plasma membrane. Used to study inflammatory bowel disease 16. Orthologous to human TNFSF15 (TNF superfamily member 15).
Rat Tnfsf15 Target Information
- Target Symbol: Tnfsf15, TNF superfamily member 15
- Alias:
- TNF ligand-related molecule 1
- Tnlg1b
- tumor necrosis factor (ligand) superfamily, member 15
- tumor necrosis factor ligand 1b
- tumor necrosis factor ligand superfamily member 15
- tumor necrosis factor superfamily member 15
- vascular endothelial cell growth inhibitor
- NCBI_Gene: 252878
Rat Tnfsf15 Predicted Functions
Enables death receptor binding activity. Involved in activation of cysteine-type endopeptidase activity involved in apoptotic process and positive regulation of cytokine production. Predicted to be located in plasma membrane. Orthologous to human TNFSF15 (TNF superfamily member 15).
