HGNC ID: 3675
Target Abstract:
Fibroblast growth factor 19 (FGF-19) is encoded by the FGF-19 gene in humans. FGF-19 regulates the synthesis of bile acids through FGFR4/Klotho in the liver- β The receptor complex has an inhibitory effect on CYP7A1. It was found in mouse models that FGF-19 also has metabolic effects, which can affect glucose and lipid metabolism. FGF-19 is reduced in patients with chronic diarrhea due to bile acid absorption disorders. FGF-19 is also present in the liver of patients with bile stasis. The expression of FGF-19 is reduced in patients with metabolic syndrome, non-alcoholic fatty liver disease, and insulin resistance. Obese patients who underwent Roux en Y gastric bypass surgery for weight loss showed an increase in FGF-19 to normal levels.
FGF19 Target Infomation Overview
- Target Symbol: FGF19, fibroblast growth factor 19
- Gene Groups: Fibroblast growth factor family
FGF19, fibroblast growth factor 19 Target Infomation by Species
- Human
- Mouse
- Rat
Human FGF19 Target Information
- Target Symbol: FGF19, fibroblast growth factor 19
- Alias:
- FGF-19
- NCBI_Gene: 9965
- UniProtKB: O95750
Human FGF19 Predicted Functions
Enables fibroblast growth factor receptor binding activity. Involved in several processes, including negative regulation of bile acid biosynthetic process; positive regulation of MAPK cascade; and positive regulation of glucose import. Acts upstream of or within fibroblast growth factor receptor signaling pathway and positive regulation of cell population proliferation. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space.
Mouse Fgf15 Target Information
- Target Symbol: Fgf15, fibroblast growth factor 15
- Alias:
- FGF19
- NCBI_Gene: 14170
Mouse Fgf15 Predicted Functions
Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Acts upstream of or within several processes, including negative regulation of bile acid biosynthetic process; neural crest cell migration; and response to bacterium. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including brain; branchial arch endoderm; embryo ectoderm; mesonephros; and sensory organ. Orthologous to human FGF19 (fibroblast growth factor 19).
Rat Fgf19 Target Information
- Target Symbol: Fgf19, fibroblast growth factor 19
- Alias:
- Fgf15
- Fgf8a
- fibroblast growth factor 15
- fibroblast growth factor 8a
- NCBI_Gene: 170582
- UniProtKB: Q8VI81
Rat Fgf19 Predicted Functions
Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Involved in bile acid and bile salt transport; response to ethanol; and response to organic cyclic compound. Predicted to be active in cytoplasm and extracellular space. Biomarker of alcoholic hepatitis. Orthologous to human FGF19 (fibroblast growth factor 19).
