HGNC ID: 10627
Target Abstract:
Chemokine ligand 3 (CCL3), also known as macrophage inflammatory protein 1α (MIP-1α), is a cytokine in the CC chemokine family involved in the acute inflammatory state in polymorphonuclear leukocyte recruitment and activation.The CCL3 gene is located on human chromosome 17, and its cDNAs encode a 92-amino-acid residue precursor protein, which contains a segment of 22 amino acid residue signaling peptide, and cleavage of this precursor protein produces a secreted mature protein. Like other chemokines, CCL3 is monocyte chemotactic. In addition, CCL3 has been reported to have different chemotactic and pro-adhesive effects on T lymphocytes, NK cells, cytotoxic T cells, B cells, basophils, and eosinophils.CCL3 has been identified as a stem cell inhibitor (SCI) that inhibits hematopoietic progenitor cell proliferation both in vitro and in vivo.CCL3, CCL4, and RANTES have been suggested to be inhibitors of CD8+ T cells produce important HIV suppressors.
CCL3 Target Infomation Overview
- Target Symbol: CCL3, C-C motif chemokine ligand 3
- Gene Groups: Chemokine ligands
- Alias: G0S19-1; LD78ALPHA; MIP-1-alpha
- Previous Names: SCYA3
- Alias Names: small inducible cytokine A3 (homologous to mouse Mip-1a); chemokine (C-C motif) ligand 3
CCL3, C-C motif chemokine ligand 3 Target Infomation by Species
- Human
- Mouse
- Rat
Human CCL3 Target Information
- Target Symbol: CCL3, C-C motif chemokine ligand 3
- Alias:
- C-C motif chemokine 3
- chemokine (C-C motif) ligand 3
- G0/G1 switch regulatory protein 19-1
- G0S19-1
- LD78 alpha beta
- LD78ALPHA
- macrophage inflammatory protein 1-alpha
- MIP-1-alpha
- MIP1A
- PAT 464.1
- SCYA3
- SIS-beta
- small inducible cytokine A3 (homologous to mouse Mip-1a)
- small-inducible cytokine A3
- tonsillar lymphocyte LD78 alpha protein
- NCBI_Gene: 6348
- UniProtKB: P10147
Human CCL3 Predicted Functions
Enables several functions, including calcium-dependent protein kinase C activity; chemoattractant activity; and chemokine receptor binding activity. Involved in several processes, including cellular response to cytokine stimulus; leukocyte chemotaxis; and positive regulation of intracellular signal transduction. Located in cytosol and extracellular space. Implicated in human immunodeficiency virus infectious disease. Biomarker of COVID-19; alcoholic hepatitis; glomerulonephritis (multiple); kidney failure (multiple); and systemic scleroderma.
Mouse Ccl3 Target Information
- Target Symbol: Ccl3, chemokine (C-C motif) ligand 3
- Alias:
- AI323804
- CCL3
- expressed sequence AI323804
- G0S19-1
- LD78alpha
- macrophage inflammatory protein-1 alpha
- macrophage inflammatory protein-1alpha
- MIP-1 alpha
- MIP-1alpha
- MIP1-(a)
- MIP1-alpha
- Mip1a
- Scya3
- small inducible cytokine A3
- NCBI_Gene: 20302
Mouse Ccl3 Predicted Functions
Enables chemokine activity. Involved in several processes, including astrocyte cell migration; macrophage chemotaxis; and positive regulation of macromolecule metabolic process. Located in extracellular space. Is expressed in articular cartilage; cartilage; knee joint; lung; and radius. Human ortholog(s) of this gene implicated in human immunodeficiency virus infectious disease. Orthologous to several human genes including CCL3 (C-C motif chemokine ligand 3).
Rat Ccl3 Target Information
- Target Symbol: Ccl3, C-C motif chemokine ligand 3
- Alias:
- C-C motif chemokine 3
- chemokine (C-C motif) ligand 3
- macrophage inflammatory protein 1 alpha (Small inducible cytokine A3)
- macrophage inflammatory protein 1-alpha
- MIP-1-alpha
- MIP-1a
- Scya3
- small inducible cytokine A3
- small-inducible cytokine A3
- NCBI_Gene: 25542
- UniProtKB: P50229
Rat Ccl3 Predicted Functions
Enables chemokine activity. Involved in several processes, including neutrophil chemotaxis; positive regulation of cytosolic calcium ion concentration; and positive regulation of osteoclast differentiation. Predicted to be located in cytosol and extracellular region. Predicted to be active in extracellular space. Biomarker of several diseases, including Chagas disease; anterior uveitis; nephritis (multiple); renal fibrosis; and status epilepticus. Human ortholog(s) of this gene implicated in human immunodeficiency virus infectious disease. Orthologous to several human genes including CCL3 (C-C motif chemokine ligand 3).
