Chemokine ligand 3 (CCL3), also known as macrophage inflammatory protein 1α (MIP-1α), is a cytokine in the CC chemokine family involved in the acute inflammatory state in polymorphonuclear leukocyte recruitment and activation.The CCL3 gene is located on human chromosome 17, and its cDNAs encode a 92-amino-acid residue precursor protein, which contains a segment of 22 amino acid residue signaling peptide, and cleavage of this precursor protein produces a secreted mature protein. Like other chemokines, CCL3 is monocyte chemotactic. In addition, CCL3 has been reported to have different chemotactic and pro-adhesive effects on T lymphocytes, NK cells, cytotoxic T cells, B cells, basophils, and eosinophils.CCL3 has been identified as a stem cell inhibitor (SCI) that inhibits hematopoietic progenitor cell proliferation both in vitro and in vivo.CCL3, CCL4, and RANTES have been suggested to be inhibitors of CD8+ T cells produce important HIV suppressors.