HGNC ID: 1689
Target Abstract:
CD59, also known as protectin, is expressed on all human lymphocytes, monocytes, granulocytes, and red blood cells. This protein is also expressed on non-hematopoietic cells, including endothelial cells and neurons. CD59 interacts with CD2, regulating T cell adhesion and playing a role in T cell activation. Furthermore, altered expression of CD55 and CD59 on peripheral blood cells has been observed in patients with systemic lupus erythematosus (SLE).
CD59 Target Infomation Overview
- Target Symbol: CD59, CD59 molecule (CD59 blood group)
- Gene Groups: Blood group antigens; CD molecules; LY6/PLAUR domain containing; Complement system regulators and receptors
- Alias: 16.3A5; EJ16; EJ30; EL32; G344; p18-20
- Previous Names: MIC11; MIN1; MSK21; MIN2; MIN3
- Alias Names: CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344); CD59 antigen, complement regulatory protein; CD59 molecule, complement regulatory protein; CD59 molecule
CD59, CD59 molecule (CD59 blood group) Target Infomation by Species
- Human
- Mouse
- Rat
Human CD59 Target Information
- Target Symbol: CD59, CD59 molecule (CD59 blood group)
- Alias:
- 16.3A5
- 1F5
- 1F5 antigen
- 20 kDa homologous restriction factor
- cd59 antigen
- CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344)
- CD59 blood group antigen
- CD59 glycoprotein
- CD59 molecule
- EJ16
- EJ30
- EL32
- FLJ38134
- FLJ92039
- G344
- HRF-20
- HRF20
- human leukocyte antigen MIC11
- Ly-6-like protein
- lymphocytic antigen CD59/MEM43
- MAC-IP
- MACIF
- MEM43
- MEM43 antigen
- membrane attack complex (MAC) inhibition factor
- membrane attack complex inhibition factor
- membrane inhibitor of reactive lysis
- MGC2354
- MIC11
- MIN1
- MIN2
- MIN3
- MIRL
- MSK21
- p18-20
- protectin
- surface anitgen recognized by monoclonal antibody 16.3A5
- T cell-activating protein
- NCBI_Gene: 966
- UniProtKB: P13987
Human CD59 Predicted Functions
Predicted to enable complement binding activity. Acts upstream of or within regulation of complement activation and regulation of complement-dependent cytotoxicity. Located in cell surface. Is anchored component of external side of plasma membrane. Implicated in colorectal carcinoma and ovarian cancer. Biomarker of breast carcinoma; endometrial cancer; and ovarian cancer.
Mouse Cd59a Target Information
- Target Symbol: Cd59a, CD59a antigen
- Alias:
- AA987121
- Cd59
- CD59 antigen
- expressed sequence AA987121
- protectin
- NCBI_Gene: 12509
Mouse Cd59a Predicted Functions
Predicted to enable complement binding activity. Involved in several processes, including negative regulation of angiogenesis; negative regulation of fibroblast growth factor production; and negative regulation of vascular endothelial growth factor receptor signaling pathway. Acts upstream of or within negative regulation of activation of membrane attack complex. Located in external side of plasma membrane. Is expressed in several structures, including Meckel’s cartilage; nervous system; neural retina; skeleton; and testis. Human ortholog(s) of this gene implicated in colorectal carcinoma and ovarian cancer. Orthologous to human CD59 (CD59 molecule (CD59 blood group)).
Rat Cd59 Target Information
- Target Symbol: Cd59, CD59 molecule
- Alias:
- Cb59b molecule
- CD59 antigen
- CD59 glycoprotein
- CD59 molecule, complement regulatory protein
- Cd59a
- Cd59b
- CD59b moleucle, complement regulatory protein
- MAC-inhibitory protein
- MAC-IP
- MACIF
- MACIP
- membrane attack complex inhibition factor
- protectin
- NCBI_Gene: 25407
- UniProtKB: P27274
Rat Cd59 Predicted Functions
Enables complement binding activity. Involved in several processes, including negative regulation of activation of membrane attack complex; negative regulation of complement-dependent cytotoxicity; and positive regulation of T cell proliferation. Located in compact myelin; extracellular space; and sarcolemma. Used to study anterior uveitis; colorectal carcinoma; glomerulonephritis; nephrosis; and neuromyelitis optica. Biomarker of acute necrotizing pancreatitis; diabetic retinopathy; and myocardial infarction. Human ortholog(s) of this gene implicated in colorectal carcinoma and ovarian cancer. Orthologous to human CD59 (CD59 molecule (CD59 blood group)).