HGNC ID: 7156
Target Abstract:
Matrix metalloproteinase 10 (MMP-10), also known as stromatolysin-2, is encoded by the MMP10 gene in humans. This gene is part of the MMP gene cluster located on chromosome 11q 22.3. Mmp-10 degrades proteoglycans and fibronectin and plays an important role in the degradation of extracellular matrix under various pathological conditions. MMP-10 is strongly expressed in osteoclasts and most monocytes in bone marrow, is induced by cytokines in human keratinocytes, and is also expressed in human head and neck cancer and lung cancer cells. The overexpression of MMP-10 in the corneal epithelium of diabetic patients may be the main factor of diabetic retinopathy. MMP-10 is related to the viability and metastasis of tumor stem cells.
MMP10 Target Infomation Overview
- Target Symbol: MMP10, matrix metallopeptidase 10
- Gene Groups: M10 matrix metallopeptidases
- Previous Names: STMY2
- Alias Names: matrix metalloproteinase 10 (stromelysin 2); stromelysin 2
MMP10, matrix metallopeptidase 10 Target Infomation by Species
- Human
- Mouse
- Rat
Human MMP10 Target Information
- Target Symbol: MMP10, matrix metallopeptidase 10
- Alias:
- matrix metalloprotease 10
- matrix metalloproteinase 10 (stromelysin 2)
- matrix metalloproteinase-10
- MMP-10
- SL-2
- STMY2
- stromelysin 2
- stromelysin-2
- transin 2
- transin-2
- NCBI_Gene: 4319
- UniProtKB: P09238
Human MMP10 Predicted Functions
Predicted to enable metalloendopeptidase activity. Predicted to be involved in collagen catabolic process and extracellular matrix organization. Predicted to act upstream of or within regulation of cell migration. Predicted to be located in extracellular space. Biomarker of adrenoleukodystrophy; diabetes mellitus; and end stage renal disease.
Mouse Mmp10 Target Information
- Target Symbol: Mmp10, matrix metallopeptidase 10
- Alias:
- AV377895
- expressed sequence AV377895
- stromelysin 2
- NCBI_Gene: 17384
Mouse Mmp10 Predicted Functions
Predicted to enable metalloendopeptidase activity. Acts upstream of or within regulation of cell migration. Predicted to be located in extracellular matrix and extracellular region. Is expressed in gonad; ovary; and testis. Orthologous to human MMP10 (matrix metallopeptidase 10).
Rat Mmp10 Target Information
- Target Symbol: Mmp10, matrix metallopeptidase 10
- Alias:
- matrix metallopeptidase 10 (stromelysin 2)
- matrix metalloproteinase 10
- matrix metalloproteinase-10
- MMP-10
- SL-2
- stromelysin 2
- stromelysin-2
- transformation-associated protein 34A
- transin-2
- NCBI_Gene: 117061
Rat Mmp10 Predicted Functions
Predicted to enable metalloendopeptidase activity. Predicted to be involved in collagen catabolic process and extracellular matrix organization. Predicted to act upstream of or within regulation of cell migration. Predicted to be located in extracellular matrix and extracellular region. Orthologous to human MMP10 (matrix metallopeptidase 10).
