HGNC ID: 3221
Target Abstract:
Ephrin-A1, also known as EFNA1, is encoded by the EFNA1 gene in humans, which encodes members of the Eph family. The ephrins and Eph related receptors form the largest receptor tyrosine kinase subfamily and are involved in regulating the development of the nervous and hematopoietic systems. According to their structure and sequence relationship, ephrins can be divided into ephrin-A (EFNA) class and ephrin-B (EFNB) class. The Ephrin-A ligand binds to the EphA receptor and is anchored to the plasma membrane through glycosylphosphatidylinositol (GPI) connections. The ephrin-B ligand binds to the EphB receptor and is anchored to the plasma membrane through a transmembrane domain. Ephrin-A1 and one of its receptors, EphA2, are expressed in xenograft endothelial cells and tumor cells, and can play a role in human cancer to some extent by influencing tumor neovascularization.
EFNA1 Target Infomation Overview
- Target Symbol: EFNA1, ephrin A1
- Gene Groups: Ephrins
- Alias: LERK1; ECKLG; GMAN
- Previous Names: TNFAIP4; EPLG1
- Alias Names: EPH-related receptor tyrosine kinase ligand 1; Tumor necrosis factor alpha-induced protein 4; gastric cancer metastasis associated long noncoding RNA; ephrin-A1
EFNA1, ephrin A1 Target Infomation by Species
- Human
- Mouse
- Rat
Human EFNA1 Target Information
- Target Symbol: EFNA1, ephrin A1
- Alias:
- B61
- ECKLG
- EFL1
- eph-related receptor tyrosine kinase ligand 1
- ephrin-A1
- EPLG1
- gastric cancer metastasis associated long noncoding RNA
- GMAN
- immediate early response protein B61
- LERK-1
- LERK1
- ligand of eph-related kinase 1
- TNF alpha-induced protein 4
- TNFAIP4
- tumor necrosis factor alpha-induced protein 4
- tumor necrosis factor, alpha-induced protein 4
- NCBI_Gene: 1942
- UniProtKB: P20827
Human EFNA1 Predicted Functions
Enables ephrin receptor binding activity. Involved in several processes, including ephrin receptor signaling pathway; protein stabilization; and regulation of protein metabolic process. Predicted to be located in extracellular region. Predicted to be active in plasma membrane. Predicted to be anchored component of plasma membrane.
Mouse Efna1 Target Information
- Target Symbol: Efna1, ephrin A1
- Alias:
- AI325262
- B61
- EFL-1
- eph-related receptor tyrosine kinase ligand 1
- Epl1
- Eplg1
- expressed sequence AI325262
- LERK-1
- Lerk1
- NCBI_Gene: 13636
Mouse Efna1 Predicted Functions
Enables ephrin receptor binding activity. Involved in several processes, including heart valve morphogenesis; negative regulation of dendritic spine morphogenesis; and regulation of blood vessel endothelial cell migration. Acts upstream of or within several processes, including ephrin receptor signaling pathway; nervous system development; and regulation of MAPK cascade. Is anchored component of plasma membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Orthologous to human EFNA1 (ephrin A1).
Rat Efna1 Target Information
- Target Symbol: Efna1, ephrin A1
- Alias:
- B61
- EPH-related receptor tyrosine kinase ligand 1
- ephrin-A1
- immediate early response protein B61
- LERK-1
- NCBI_Gene: 94268
- UniProtKB: P97553
Rat Efna1 Predicted Functions
Predicted to enable ephrin receptor binding activity. Predicted to be involved in several processes, including cell morphogenesis involved in differentiation; heart valve morphogenesis; and regulation of protein metabolic process. Predicted to act upstream of or within several processes, including negative regulation of thymocyte apoptotic process; nervous system development; and regulation of MAPK cascade. Predicted to be located in extracellular region. Predicted to be active in plasma membrane. Predicted to be anchored component of plasma membrane. Orthologous to human EFNA1 (ephrin A1).
