HGNC ID: 11822
Target Abstract:
Tissue metalloproteinase inhibitor 3 (TIMP-3) is a protein encoded by the TIMP3 gene and belongs to the tissue inhibitor family of metalloproteinase genes. There are four members of the family: TIMP-1, TIMP-2, TIMP-3 and TIMP-4. TIMP-3 is a 30 kDa glycoprotein secreted by many types of cells. TIMP-3 inhibits active MMP-mediated proteolysis by forming a non-covalent binary complex with the MMP active site through its N-terminal domain. In addition, TIMP-3 is also an inflammatory factor inhibitor, which negatively regulates TACE and promotes the release of TNF-α, which in turn causes inflammation and vascular remodeling in the body. This gene mutation is associated with autosomal dominant Sorsby fundus dystrophy.
TIMP3 Target Infomation Overview
- Target Symbol: TIMP3, TIMP metallopeptidase inhibitor 3
- Gene Groups: Tissue inhibitor of metallopeptidases
- Previous Names: SFD
- Alias Names: tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory)
TIMP3, TIMP metallopeptidase inhibitor 3 Target Infomation by Species
- Human
- Mouse
- Rat
Human TIMP3 Target Information
- Target Symbol: TIMP3, TIMP metallopeptidase inhibitor 3
- Alias:
- HSMRK222
- K222
- K222TA2
- metalloproteinase inhibitor 3
- MIG-5 protein
- protein MIG-5
- SFD
- TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory)
- TIMP-3
- tissue inhibitor of metalloproteinase 3
- tissue inhibitor of metalloproteinases 3
- NCBI_Gene: 7078
- UniProtKB: P35625
Human TIMP3 Predicted Functions
Predicted to enable metalloendopeptidase inhibitor activity and protease binding activity. Involved in negative regulation of ERK1 and ERK2 cascade; negative regulation of membrane protein ectodomain proteolysis; and positive regulation of TRAIL-activated apoptotic signaling pathway. Located in nucleus. Colocalizes with collagen-containing extracellular matrix. Implicated in Sorsby’s fundus dystrophy; breast carcinoma; and urinary bladder cancer. Biomarker of several diseases, including breast cancer (multiple); preretinal fibrosis; reproductive organ cancer (multiple); thoracic aortic aneurysm; and type 2 diabetes mellitus.
Mouse Timp3 Target Information
- Target Symbol: Timp3, tissue inhibitor of metalloproteinase 3
- Alias:
- Timp-3
- NCBI_Gene: 21859
Mouse Timp3 Predicted Functions
Predicted to enable metalloendopeptidase inhibitor activity and protease binding activity. Involved in negative regulation of metalloendopeptidase activity. Acts upstream of or within cellular response to organic substance. Located in basement membrane. Is expressed in several structures, including alimentary system; central nervous system; eye posterior segment; genitourinary system; and musculoskeletal system. Used to study Sorsby’s fundus dystrophy and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in Sorsby’s fundus dystrophy; breast carcinoma; and urinary bladder cancer. Orthologous to human TIMP3 (TIMP metallopeptidase inhibitor 3).
Rat Timp3 Target Information
- Target Symbol: Timp3, TIMP metallopeptidase inhibitor 3
- Alias:
- metalloproteinase inhibitor 3
- TIMP-3
- tissue inhibitor of metalloproteinase 3
- tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory)
- tissue inhibitor of metalloproteinases 3
- NCBI_Gene: 25358
Rat Timp3 Predicted Functions
Predicted to enable metalloendopeptidase inhibitor activity; protease binding activity; and zinc ion binding activity. Involved in several processes, including negative regulation of proteolysis; response to estrogen; and response to folic acid. Located in cytoplasm. Human ortholog(s) of this gene implicated in Sorsby’s fundus dystrophy; breast carcinoma; and urinary bladder cancer. Orthologous to human TIMP3 (TIMP metallopeptidase inhibitor 3).
