HGNC ID: 1663
Target Abstract:
CD36 is an 85kDa glycoprotein, also known as GPIIIb or GPI. It acts as a receptor for extracellular matrix proteins such as collagen and thrombospondin. The CD36 antigen is expressed on monocytes, platelets, endothelial cells, and some human tumor cell lines, but not on lymphocytes and granulocytes. It serves as an early marker of erythroid differentiation. CD36 is known to mediate the adhesion of pathogenic malaria parasites. CD36 antibodies can induce cell degranulation, release of ATP and 5-hydroxytryptamine, increase in intracellular calcium concentration ([Ca2+]) and tyrosine phosphorylation of a 130kDa substrate protein. CD36 can interact with thrombospondin, long-chain fatty acids, oxidized LDL, collagen types I, IV, and V, as well as apoptotic cells.
CD36 Target Infomation Overview
- Target Symbol: CD36, CD36 molecule
- Gene Groups: CD molecules; Scavenger receptors
- Alias: SCARB3; GPIV; FAT; GP4; GP3B
- Alias Names: CD36 antigen (collagen type I receptor, thrombospondin receptor); CD36 molecule (thrombospondin receptor)
CD36, CD36 molecule Target Infomation by Species
- Human
- Mouse
- Rat
Human CD36 Target Information
- Target Symbol: CD36, CD36 molecule
- Alias:
- BDPLT10
- CD36 antigen (collagen type I receptor, thrombospondin receptor)
- CD36 molecule (thrombospondin receptor)
- CHDS7
- cluster determinant 36
- FAT
- fatty acid translocase
- glycoprotein IIIb
- GP3B
- GP4
- GPIIIB
- GPIV
- leukocyte differentiation antigen CD36
- PAS IV
- PAS-4 protein
- PASIV
- platelet glycoprotein 4
- platelet glycoprotein IV
- SCARB3
- scavenger receptor class B, member 3
- NCBI_Gene: 948
- UniProtKB: P16671
Human CD36 Predicted Functions
Enables several functions, including amyloid-beta binding activity; fatty acid transmembrane transporter activity; and low-density lipoprotein particle binding activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; lipid transport; and second-messenger-mediated signaling. Located in several cellular components, including Golgi apparatus; cell surface; and membrane raft. Part of receptor complex. Implicated in several diseases, including blood platelet disease (multiple); hemolytic-uremic syndrome; osteoarthritis; pulmonary tuberculosis; and type 2 diabetes mellitus. Biomarker of several diseases, including autoimmune disease (multiple); myeloid neoplasm (multiple); myositis (multiple); rheumatic heart disease; and sickle cell anemia.
Mouse Cd36 Target Information
- Target Symbol: Cd36, CD36 molecule
- Alias:
- FAT
- fatty acid translocase
- Scarb3
- NCBI_Gene: 12491
Mouse Cd36 Predicted Functions
Enables lipoprotein particle binding activity; lipoteichoic acid immune receptor activity; and low-density lipoprotein particle receptor activity. Involved in several processes, including lipid transport; regulation of gene expression; and regulation of reactive oxygen species metabolic process. Acts upstream of or within several processes, including phagocytosis; positive regulation of cytokine production; and response to bacterium. Located in several cellular components, including brush border membrane; external side of plasma membrane; and membrane raft. Is expressed in several structures, including Meckel’s cartilage; axial skeleton; bone; hindlimb; and telencephalon. Used to study platelet-type bleeding disorder 10. Human ortholog(s) of this gene implicated in several diseases, including blood platelet disease (multiple); hemolytic-uremic syndrome; osteoarthritis; pulmonary tuberculosis; and type 2 diabetes mellitus. Orthologous to human CD36 (CD36 molecule).
Rat Cd36 Target Information
- Target Symbol: Cd36, CD36 molecule
- Alias:
- adipocyte membrane protein
- CD36 antigen
- CD36 antigen (collagen type I receptor, thrombospondin receptor)
- Cd36 antigen-like
- CD36 molecule (thrombospondin receptor)
- collagen type I receptor thrombospondin receptor
- Fat
- fatty acid translocase
- fatty acid transport protein
- glycoprotein IIIb
- GPIIIB
- GPIV
- LOC499984
- MGC108510
- MGC91634
- PAS IV
- PAS-4
- platelet glycoprotein 4
- platelet glycoprotein IV
- RGD1562323
- similar to fatty acid translocase/CD36
- NCBI_Gene: 29184
Rat Cd36 Predicted Functions
Enables several functions, including oleic acid binding activity; scavenger receptor activity; and thrombospondin receptor activity. Involved in several processes, including fatty acid metabolic process; positive regulation of macromolecule metabolic process; and response to peptide hormone. Located in several cellular components, including brush border membrane; caveola; and sarcolemma. Part of protein-containing complex. Used to study interstitial lung disease (multiple); macular degeneration; myocardial infarction; obesity; and polycystic ovary syndrome. Biomarker of artery disease (multiple); hypertrophic cardiomyopathy; nephrosis; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including blood platelet disease (multiple); hemolytic-uremic syndrome; osteoarthritis; pulmonary tuberculosis; and type 2 diabetes mellitus. Orthologous to human CD36 (CD36 molecule).