HGNC ID: 1628
Target Abstract: CD14 is a glycoprotein expressed on the surface of monocytes, macrophages in follicles, and dendritic cell subsets. CD14 forms a receptor complex with MD-2(LY) and TLR4, which specifically responds and transduces signals to lipopolysaccharide (LPS). The CD14/MD-2/TLR4 receptor complex signals through MyD88, TIRAP, and TRAF6, ultimately activating NF-κB.
CD14 Target Infomation Overview
- Target Symbol: CD14, CD14 molecule
- Gene Groups: CD molecules; Scavenger receptors
- Alias Names: CD14 antigen
CD14, CD14 molecule Target Infomation by Species
- Human
- Mouse
- Rat
Human CD14 Target Information
- Target Symbol: CD14, CD14 molecule
- Alias:
- cd14 antigen
- monocyte differentiation antigen CD14
- myeloid cell-specific leucine-rich glycoprotein
- NCBI_Gene: 929
- UniProtKB: P08571
Human CD14 Predicted Functions
Enables lipopeptide binding activity; lipopolysaccharide binding activity; and lipoteichoic acid binding activity. Involved in cellular response to bacterial lipopeptide; positive regulation of NIK/NF-kappaB signaling; and positive regulation of interleukin-8 production. Acts upstream of or within cellular response to lipopolysaccharide; cellular response to lipoteichoic acid; and positive regulation of tumor necrosis factor production. Located in Golgi apparatus and membrane raft. Is anchored component of external side of plasma membrane. Part of lipopolysaccharide receptor complex. Implicated in several diseases, including IgA glomerulonephritis; artery disease (multiple); celiac disease; cystic fibrosis; and pulmonary tuberculosis. Biomarker of several diseases, including biliary atresia; cystic fibrosis; lung disease (multiple); perinatal necrotizing enterocolitis; and polycystic kidney disease (multiple).
Mouse Cd14 Target Information
- Target Symbol: Cd14, CD14 antigen
- Alias:
- -
- NCBI_Gene: 12475
Mouse Cd14 Predicted Functions
Predicted to enable lipopeptide binding activity; lipopolysaccharide binding activity; and lipoteichoic acid binding activity. Involved in several processes, including lipopolysaccharide-mediated signaling pathway; positive regulation of cytokine production; and toll-like receptor 4 signaling pathway. Located in external side of plasma membrane and membrane raft. Is expressed in several structures, including femur; gallbladder; intestine; reproductive system; and telencephalon. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; artery disease (multiple); celiac disease; cystic fibrosis; and perinatal necrotizing enterocolitis. Orthologous to human CD14 (CD14 molecule).
Rat Cd14 Target Information
- Target Symbol: Cd14, CD14 molecule
- Alias:
- CD14 antigen
- monocyte differentiation antigen CD14
- myeloid cell-specific leucine-rich glycoprotein
- NCBI_Gene: 60350
- UniProtKB: Q63691
大鼠 Rat Cd14 Predicted Functions
Predicted to enable lipopeptide binding activity; lipopolysaccharide binding activity; and lipoteichoic acid binding activity. Involved in several processes, including cellular response to lipopolysaccharide; response to magnesium ion; and response to tumor necrosis factor. Located in cell surface; extracellular space; and plasma membrane. Used to study perinatal necrotizing enterocolitis. Biomarker of Hirschsprung's disease; cholestasis; obstructive jaundice; and periodontitis. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; artery disease (multiple); celiac disease; cystic fibrosis; and pulmonary tuberculosis. Orthologous to human CD14 (CD14 molecule).
