HGNC ID: 4015
Target Abstract:
CD15 is a 220 kDa carbohydrate, also known as SSEA-1, Lewis 3-fucosyl N-acetyllactoamine (3-FAL). CD15 is expressed on most granulocytes and monocytes, but not on lymphocytes. It participates in cell adhesion, chemotaxis, and phagocytosis.
FUT4 Target Infomation Overview
- Target Symbol: FUT4, fucosyltransferase 4
- Gene Groups: Fucosyltransferases; CD molecules
- Alias: FUC-TIV
- Previous Names: CD15; FCT3A; ELFT
- Alias Names: galactoside 3-L-fucosyltransferase; alpha (1,3) fucosyltransferase, myeloid-specific; ELAM ligand fucosyltransferase
FUT4, fucosyltransferase 4 Target Infomation by Species
- Human
- Mouse
- Rat
Human FUT4 Target Information
- Target Symbol: FUT4, fucosyltransferase 4
- Alias:
- alpha (1,3) fucosyltransferase, myeloid-specific
- alpha-(1,3)-fucosyltransferase
- alpha-(1,3)-fucosyltransferase 4
- CD15
- ELAM ligand fucosyltransferase
- ELAM-1 ligand fucosyltransferase
- ELFT
- FCT3A
- FUC-TIV
- fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
- fucosyltransferase IV
- fucT-IV
- FUTIV
- galactoside 3-L-fucosyltransferase
- Lewis X
- LeX
- SSEA-1
- stage-specific embryonic antigen 1
- NCBI_Gene: 2526
- UniProtKB: P22083
Human FUT4 Predicted Functions
Enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity. Involved in oligosaccharide metabolic process and regulation of leukocyte cell-cell adhesion. Located in trans-Golgi network.
Mouse Fut4 Target Information
- Target Symbol: Fut4, fucosyltransferase 4
- Alias:
- 3-fucosyl-N-acetyl-lactosamine epitope
- AI451562
- expressed sequence AI451562
- FAL
- FucT-IV
- LeX
- SSEA-1
- Ssea1
- NCBI_Gene: 14345
Mouse Fut4 Predicted Functions
Predicted to enable 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity. Involved in positive regulation of leukocyte tethering or rolling. Located in cell periphery and cell surface. Is expressed in several structures, including ear; embryo ectoderm; extraembryonic component; genitourinary system; and gut. Orthologous to human FUT4 (fucosyltransferase 4).
Rat Fut4 Target Information
- Target Symbol: Fut4, fucosyltransferase 4
- Alias:
- alpha 1,3-fucosyltransferase Fuc-T (similar to mouse Fut4)
- alpha 13-fucosyltransferase Fuc-T (similar to mouse Fut4)
- alpha-(1,3)-fucosyltransferase
- alpha-(1,3)-fucosyltransferase 4
- fuc-TIV
- fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
- fucosyltransferase IV
- Fuct
- fucT-IV
- galactoside 3-L-fucosyltransferase
- NCBI_Gene: 60670
Rat Fut4 Predicted Functions
Enables alpha-(1->3)-fucosyltransferase activity. Predicted to be involved in fucosylation; oligosaccharide metabolic process; and positive regulation of leukocyte tethering or rolling. Predicted to be located in cell periphery; cell surface; and trans-Golgi network. Orthologous to human FUT4 (fucosyltransferase 4).