Target Abstract: Oncostatin-M-specific receptor subunit beta, also known as OSMR, is a member of the type I cytokine receptor family. OSMR contains four fibronectin type-III domains and is expressed at relatively high levels in all neural cells as well as fibroblast, epithelial and a variety of tumor celllines.This protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Defects in OSMR are the cause of amyloidosis type 9 which is a hereditary primary amyloidosis characterized by localized cutaneous amyloid deposition.
OSMR Target Infomation Overview
- Target Symbol: OSMR, oncostatin M receptor
- Gene Groups: Fibronectin type III domain containing
- Alias: OSMRB; OSMRbeta
- Alias Names: Oncostatin-M-specific receptor subunit beta
OSMR, oncostatin M receptor Target Infomation by Species
- Human
- Mouse
- Rat
Human OSMR Target Information
- Target Symbol: OSMR, oncostatin M receptor
- Alias:
- IL-31 receptor subunit beta
- IL-31R subunit beta
- IL-31R-beta
- IL-31RB
- interleukin-31 receptor subunit beta
- MGC150626
- MGC150627
- MGC75127
- oncostatin-M specific receptor beta subunit
- oncostatin-M-specific receptor subunit beta
- OSMRB
- OSMRbeta
- PLCA1
- NCBI_Gene: 9180
- UniProtKB: Q99650
Human OSMR Predicted Functions
Enables growth factor binding activity. Contributes to oncostatin-M receptor activity. Involved in oncostatin-M-mediated signaling pathway and positive regulation of cell population proliferation. Part of apical plasma membrane and oncostatin-M receptor complex. Implicated in primary localized cutaneous amyloidosis 1.
Mouse Mouse Osmr Target Information
- Target Symbol: Osmr, oncostatin M receptor
- Alias:
- OSMRB
- NCBI_Gene: 18414
Mouse Osmr Predicted Functions
Enables cytokine binding activity and oncostatin-M receptor activity. Predicted to be involved in oncostatin-M-mediated signaling pathway and positive regulation of cell population proliferation. Predicted to act upstream of or within cell surface receptor signaling pathway. Located in external side of plasma membrane. Is expressed in several structures, including cardiovascular system; hemolymphoid system; lung; sensory organ; and skeletal system. Human ortholog(s) of this gene implicated in primary localized cutaneous amyloidosis 1. Orthologous to human OSMR (oncostatin M receptor).
Rat Osmr Target Information
- Target Symbol: Osmr, oncostatin M receptor
- Alias:
- IL-31 receptor subunit beta
- IL-31R subunit beta
- IL-31R-beta
- IL-31RB
- interleukin-31 receptor subunit beta
- oncostatin M specific receptor
- oncostatin-M specific receptor subunit beta
- oncostatin-M-specific receptor subunit beta
- NCBI_Gene: 310132
Rat Osmr Predicted Functions
Predicted to enable several functions, including ciliary neurotrophic factor receptor binding activity; cytokine receptor activity; and growth factor binding activity. Predicted to contribute to oncostatin-M receptor activity. Predicted to be involved in oncostatin-M-mediated signaling pathway and positive regulation of cell population proliferation. Predicted to be located in apical plasma membrane. Predicted to be part of oncostatin-M receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in primary localized cutaneous amyloidosis 1. Orthologous to human OSMR (oncostatin M receptor).