Target Abstract: FGFR3, also known as CD333, is a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. FGFRs are transmembrane catalytic receptors that have intracellular tyrosine kinase activity. Mutations in FGFR genes are the cause of several human developmental disorders characterized by skeletal abnormalities such as achondroplasia, and upregulation of FGFR expression may lead to cell transformation and cancer. FGFR3, a full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR3 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR3 binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. CD333 is the receptor for acidic and basic fibroblast growth factors.
FGFR3 Target Infomation Overview
- Target Symbol: FGFR3, fibroblast growth factor receptor 3
- Gene Groups: I-set domain containing; Receptor tyrosine kinases; CD molecules
- Alias: CEK2; JTK4; CD333, ACH
- Alias Names: achondroplasia, thanatophoric dwarfism
FGFR3, fibroblast growth factor receptor 3 Target Infomation by Species
- Human
- Mouse
- Rat
Human FGFR3 Target Information
- Target Symbol: FGFR3, fibroblast growth factor receptor 3
- Alias:
- ACH
- achondroplasia, thanatophoric dwarfism
- CD333
- CEK2
- FGFR-3
- fibroblast growth factor receptor 3 variant 4
- fibroblast growth factor receptor 3-S
- HSFGFR3EX
- hydroxyaryl-protein kinase
- JTK4
- tyrosine kinase JTK4
- NCBI_Gene: 2261
- UniProtKB: P22607
Human FGFR3 Predicted Functions
Enables fibroblast growth factor binding activity; fibroblast growth factor receptor activity; and identical protein binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of intracellular signal transduction; and positive regulation of tyrosine phosphorylation of STAT protein. Located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and transport vesicle. Implicated in several diseases, including Human papillomavirus infectious disease; SADDAN; acanthosis nigricans; bone disease (multiple); and carcinoma (multiple). Biomarker of several diseases, including Merkel cell carcinoma; chronic myeloid leukemia; gastrointestinal system cancer (multiple); thanatophoric dysplasia; and urinary bladder cancer (multiple).
Mouse Fgfr3 Target Information
- Target Symbol: Fgfr3, fibroblast growth factor receptor 3
- Alias:
- Fgfr-3
- HBGFR
- sam3
- NCBI_Gene: 14184
Mouse Fgfr3 Predicted Functions
Enables fibroblast growth factor receptor activity and miRNA binding activity. Involved in several processes, including bone development; post-anal tail morphogenesis; and response to sodium phosphate. Acts upstream of or within several processes, including epithelial cell differentiation; negative regulation of cell differentiation; and nervous system development. Located in cytoplasmic side of plasma membrane; lysosome; and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; brain; respiratory system; sensory organ; and skeleton. Used to study Muenke Syndrome; achondroplasia; hypochondroplasia; scoliosis; and thanatophoric dysplasia. Human ortholog(s) of this gene implicated in several diseases, including Human papillomavirus infectious disease; SADDAN; acanthosis nigricans; bone disease (multiple); and carcinoma (multiple). Orthologous to human FGFR3 (fibroblast growth factor receptor 3).
Rat Fgfr3 Target Information
- Target Symbol: Fgfr3, fibroblast growth factor receptor 3
- Alias:
- -
- NCBI_Gene: 84489
Rat Fgfr3 Predicted Functions
Enables fibroblast growth factor binding activity and fibroblast growth factor receptor activity. Involved in cell-cell signaling; fibroblast growth factor receptor signaling pathway; and positive regulation of cell population proliferation. Located in cell surface. Biomarker of chondrosarcoma. Human ortholog(s) of this gene implicated in several diseases, including Human papillomavirus infectious disease; SADDAN; acanthosis nigricans; bone disease (multiple); and carcinoma (multiple). Orthologous to human FGFR3 (fibroblast growth factor receptor 3).
