HGNC ID: 12680
Target Abstract:
Vascular endothelial growth factors (VEGF) are a subfamily of growth factors, specifically belonging to the platelet-derived growth factor (PDGF) family of cystine knot growth factors. They are important signaling proteins involved in angiogenesis (formation of the embryonic circulatory system from the ground up) and angiogenesis (formation of blood vessels from the growth of the pre-existing vascular system).VEGF stimulates both angiogenesis and angiogenesis. It can be involved in reverting the tissue oxygenation system when circulation is inadequate.The most important role of VEGF is angiogenesis. During embryogenesis, VEGF regulates the proliferation, migration, and survival of endothelial cells, which in turn regulates blood vessel density and size, but does not determine the type of blood vessel. In patients with bronchial asthma and diabetes, serum contains high concentrations of VEGF, which causes disease when overexpressed. Solid tumors are limited in size when the blood supply is inadequate; tumors that express VEGF grow and metastasize. overexpression of VEGF causes vascular disease in the retina of the eye and other parts of the body. Bevacizumab and ranibizumab inhibit VEGF and control or slow the disease process.
VEGFA Target Infomation Overview
- Target Symbol: VEGFA, vascular endothelial growth factor A
- Gene Groups: VEGF family
- Alias: VEGF-A; VPF
- Previous Names: VEGF
- Alias Names: vascular endothelial growth factor
VEGFA, vascular endothelial growth factor A Target Infomation by Species
- Human
- Mouse
- Rat
Human VEGFA Target Information
- Target Symbol: VEGFA, vascular endothelial growth factor A
- Alias:
- MGC70609
- MVCD1
- vascular endothelial growth factor
- vascular endothelial growth factor A121
- vascular endothelial growth factor A165
- vascular permeability factor
- VEGF
- VEGF-A
- VPF
- NCBI_Gene: 7422
- UniProtKB: P15692
Human VEGFA Predicted Functions
Enables several functions, including fibronectin binding activity; heparin binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of cell migration; positive regulation of intracellular signal transduction; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including branching involved in blood vessel morphogenesis; positive regulation of endothelial cell proliferation; and regulation of nitric oxide mediated signal transduction. Located in several cellular components, including adherens junction; cell surface; and secretory granule. Implicated in several diseases, including autoimmune disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); hypertension (multiple); and reproductive organ cancer (multiple). Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); inflammatory bowel disease (multiple); and respiratory system cancer (multiple).
Mouse Vegfa Target Information
- Target Symbol: Vegfa, vascular endothelial growth factor A
- Alias:
- vascular endothelial growth factor
- Vegf
- VEGF-A
- VEGF120
- VEGF164
- VEGF188
- VPF
- NCBI_Gene: 22339
Mouse Vegfa Predicted Functions
Enables extracellular matrix binding activity; heparin binding activity; and signaling receptor binding activity. Involved in several processes, including generation of neurons; regulation of signal transduction; and vasculature development. Acts upstream of or within several processes, including animal organ development; positive regulation of cell population proliferation; and vasculature development. Located in cytoplasm; extracellular space; and nucleus. Is expressed in several structures, including alimentary system; brain; egg cylinder; genitourinary system; and heart. Used to study DiGeorge syndrome; amyotrophic lateral sclerosis type 1; newborn respiratory distress syndrome; and psoriasis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human VEGFA (vascular endothelial growth factor A).
Rat Vegfa Target Information
- Target Symbol: Vegfa, vascular endothelial growth factor A
- Alias:
- vascular endothelial growth factor
- vascular permeability factor
- Vegf
- VEGF-A
- VEGF111
- VEGF164
- VPF
- NCBI_Gene: 83785
Rat Vegfa Predicted Functions
Enables several functions, including identical protein binding activity; receptor ligand activity; and vascular endothelial growth factor receptor 2 binding activity. Involved in several processes, including negative regulation of cell death; response to steroid hormone; and response to vitamin. Located in basement membrane; extracellular space; and vesicle. Used to study several diseases, including brain edema; limb ischemia; middle cerebral artery infarction; ovarian hyperstimulation syndrome; and proliferative diabetic retinopathy. Biomarker of several diseases, including adhesions of uterus; attention deficit hyperactivity disorder; brain edema; liver disease (multiple); and retinal vascular disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); hypertension (multiple); and reproductive organ cancer (multiple). Orthologous to human VEGFA (vascular endothelial growth factor A).
