HGNC ID: 663
Target Abstract:
Arginase is a key element in the urea cycle, catalyzing the conversion of L-arginine to urea and L-ornithine, thereby promoting collagen synthesis and cell proliferation. Arginine metabolism is a critical regulatory factor in innate and adaptive immune responses and is involved in the antibacterial effects of polymorphonuclear leukocytes (PMNs). During PMN apoptosis, arginine is depleted in the microenvironment, leading to the inhibition of T-cell and natural killer cell proliferation and cytokine secretion. Arginase 1 (ARG1) is a member of the arginase family and has a molecular weight of 35-40 kDa. It is expressed in various cell types, including erythrocytes, hepatocytes, neutrophils, smooth muscle cells, and macrophages. Human ARG1 consists of 322 amino acids (aa), with the enzyme domain located from aa 9 to 309 and containing two Mn atoms. The monomer of ARG1 exhibits moderate activity, but as a homotrimer of 105 kDa, it displays high activity.
ARG1 Target Infomation Overview
- Target Symbol: ARG1, arginase 1
- Alias Names: arginase-1; arginase, liver
ARG1, arginase 1 Target Infomation by Species
- Human
- Mouse
- Rat
Human ARG1 Target Information
- Target Symbol: ARG1, arginase 1
- Alias:
- arginase-1
- arginase, liver
- liver-type arginase
- type I arginase
- NCBI_Gene: 383
- UniProtKB: P05089
Human ARG1 Predicted Functions
Predicted to enable arginase activity and manganese ion binding activity. Involved in negative regulation of T cell proliferation; negative regulation of interferon-gamma-mediated signaling pathway; and positive regulation of neutrophil mediated killing of fungus. Located in extracellular space. Implicated in asthma; hepatocellular carcinoma; and hyperargininemia. Biomarker of asthma and colitis.
Mouse Arg1 Target Information
- Target Symbol: Arg1, arginase, liver
- Alias:
- AI
- AI256583
- Arg-1
- expressed sequence AI256583
- PGIF
- NCBI_Gene: 11846
Mouse Arg1 Predicted Functions
Enables arginase activity. Involved in defense response to protozoan; negative regulation of T-helper 2 cell cytokine production; and negative regulation of activated T cell proliferation. Predicted to be located in several cellular components, including extracellular space; mitochondrial outer membrane; and neuronal cell body. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study hyperargininemia. Human ortholog(s) of this gene implicated in asthma; hepatocellular carcinoma; and hyperargininemia. Orthologous to human ARG1 (arginase 1).
Rat Arg1 Target Information
- Target Symbol: Arg1, arginase 1
- Alias:
- AI type I arginase
- AI, type I arginase
- arginase 1 liver
- Arginase 1, liver
- arginase-1
- arginase, liver
- liver-type arginase
- type I arginase
- NCBI_Gene: 29221
- UniProtKB: P07824
Rat Arg1 Predicted Functions
Enables arginase activity; identical protein binding activity; and manganese ion binding activity. Involved in several processes, including cellular response to hormone stimulus; gland development; and response to vitamin. Located in several cellular components, including extracellular space; mitochondrial outer membrane; and neuronal cell body. Used to study acute necrotizing pancreatitis and hypertension. Biomarker of several diseases, including acute kidney failure; cholestasis; silicosis; ureteral obstruction; and uveitis. Human ortholog(s) of this gene implicated in asthma; hepatocellular carcinoma; and hyperargininemia. Orthologous to human ARG1 (arginase 1).
