HGNC ID: 11823
Target Abstract:
In humans, tissue metalloproteinase inhibitor 4 (TIMP-4) is a protein encoded by the TIMP4 gene in the tissue metalloproteinase inhibitor family. There are four members of the family, TIMP-1, TIMP-2, TIMP-3 and TIMP-4. Of the four known members of the TIMP family, TIMP-4 has features common to all TIMPs and its own unique features. Unlike TIMP-2, TIMP-4 does not promote the activation of MMP-2 precursors through activated MMP-14(MT1-MMP). TIMP-4 mRNA is expressed at high levels in the heart and at low levels in the kidneys, pancreas, colon and testis. TIMP-4 is expressed in breast cancer, cervical cancer, endometrial cancer, glioma and choriocarcinoma.
TIMP4 Target Infomation Overview
- Target Symbol: TIMP4, TIMP metallopeptidase inhibitor 4
- Gene Groups: Tissue inhibitor of metallopeptidases
- Alias Names: tissue inhibitor of metalloproteinase 4
TIMP4, TIMP metallopeptidase inhibitor 4 Target Infomation by Species
- Human
- Mouse
- Rat
Human TIMP4 Target Information
- Target Symbol: TIMP4, TIMP metallopeptidase inhibitor 4
- Alias:
- metalloproteinase inhibitor 4
- TIMP-4
- tissue inhibitor of metalloproteinase 4
- tissue inhibitor of metalloproteinases 4
- NCBI_Gene: 7079
- UniProtKB: Q99727
Human TIMP4 Predicted Functions
Predicted to enable metalloendopeptidase inhibitor activity and protease binding activity. Predicted to be involved in negative regulation of proteolysis; response to cytokine; and response to hormone. Predicted to act upstream of or within Notch signaling pathway. Predicted to be located in sarcomere. Predicted to be active in extracellular matrix and extracellular space. Implicated in nephroblastoma. Biomarker of ductal carcinoma in situ; female reproductive organ cancer (multiple); prostate carcinoma in situ; and renal cell carcinoma.
Mouse Timp4 Target Information
- Target Symbol: Timp4, tissue inhibitor of metalloproteinase 4
- Alias:
- TIMP-4
- NCBI_Gene: 110595
Mouse Timp4 Predicted Functions
Predicted to enable metalloendopeptidase inhibitor activity and protease binding activity. Acts upstream of or within Notch signaling pathway. Predicted to be located in sarcomere. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including brain ventricular layer; heart; ovary; skin; and ventral grey horn. Human ortholog(s) of this gene implicated in nephroblastoma. Orthologous to human TIMP4 (TIMP metallopeptidase inhibitor 4).
Rat Timp4 Target Information
- Target Symbol: Timp4, TIMP metallopeptidase inhibitor 4
- Alias:
- LOC680130
- metalloproteinase inhibitor 4
- similar to Metalloproteinase inhibitor 4 precursor (TIMP-4) (Tissue inhibitor of metalloproteinases-4)
- TIMP-4
- Timp4_mapped
- tissue inhibitor of metalloproteinase 4
- tissue inhibitor of metalloproteinase 4 (mapped)
- tissue inhibitor of metalloproteinases 4
- NCBI_Gene: 680130
- UniProtKB: P81556
Rat Timp4 Predicted Functions
Predicted to enable metalloendopeptidase inhibitor activity; protease binding activity; and zinc ion binding activity. Involved in several processes, including ovulation cycle; response to lipopolysaccharide; and response to peptide hormone. Located in extracellular space and sarcomere. Biomarker of abdominal aortic aneurysm; congestive heart failure; and renal hypertension. Human ortholog(s) of this gene implicated in nephroblastoma. Orthologous to human TIMP4 (TIMP metallopeptidase inhibitor 4).
