HGNC ID: 11923
Target Abstract:
Leukocyte antigen differentiation Cluster 30(CD30), also known as tumor necrosis factor receptor superfamily member 8 (TNFRSF8), is a membrane protein belonging to the tumor necrosis factor receptor (TNFR) superfamily. CD30 protein is expressed by activated rather than resting T and B cells. CD30 may play a role in the regulation of cell growth and activated lymphoblastic transformation, and may also play an important role in human immunodeficiency virus replication. TRAF2 and TRAF5 can interact with this receptor and mediate the formation of NF-κ B activated signal transduction. As a positive regulator of apoptosis, CD30 protein can induce cell death or proliferation depending on cell type and has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. CD30 protein expression is upregulated in a variety of hematological malignancies, and CD30 is also associated with white blood cells in patients with chronic inflammatory diseases, such as lupus erythematosus, asthma, and rheumatoid arthritis.
TNFRSF8 Target Infomation Overview
- Target Symbol: TNFRSF8, TNF receptor superfamily member 8
- Gene Groups: CD molecules; Tumor necrosis factor receptor superfamily
- Alias: KI-1
- Previous Names: CD30; D1S166E
- Alias Names: tumor necrosis factor receptor superfamily, member 8
TNFRSF8, TNF receptor superfamily member 8 Target Infomation by Species
- Human
- Mouse
- Rat
Human TNFRSF8 Target Information
- Target Symbol: TNFRSF8, TNF receptor superfamily member 8
- Alias:
- CD30
- CD30 antigen
- CD30L receptor
- cytokine receptor CD30
- D1S166E
- Ki-1
- Ki-1 antigen
- lymphocyte activation antigen CD30
- tumor necrosis factor receptor superfamily member 8
- tumor necrosis factor receptor superfamily, member 8
- NCBI_Gene: 943
- UniProtKB: P28908
Human TNFRSF8 Predicted Functions
Predicted to enable transmembrane signaling receptor activity. Involved in cellular response to mechanical stimulus; positive regulation of apoptotic process; and positive regulation of tumor necrosis factor superfamily cytokine production. Located in plasma membrane.
Mouse Tnfrsf8 Target Information
- Target Symbol: Tnfrsf8, tumor necrosis factor receptor superfamily, member 8
- Alias:
- CD30
- Cd30
- CD30 antigen
- NCBI_Gene: 21941
Mouse Tnfrsf8 Predicted Functions
Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in positive regulation of NF-kappaB transcription factor activity; positive regulation of apoptotic process; and positive regulation of tumor necrosis factor superfamily cytokine production. Predicted to be located in plasma membrane. Is expressed in several structures, including adrenal gland; brain; female reproductive system; intestine; and thymus. Orthologous to human TNFRSF8 (TNF receptor superfamily member 8).
Rat Tnfrsf8 Target Information
- Target Symbol: Tnfrsf8, TNF receptor superfamily member 8
- Alias:
- Cd30
- CD30L receptor
- lymphocyte activation antigen CD30
- tumor necrosis factor receptor superfamily member 8
- tumor necrosis factor receptor superfamily, member 8
- Tumor necrosis factor superfamily member 8
- tumor necrosis factor superfamily member CD30
- tumor necrosis factor superfamily, member CD30
- NCBI_Gene: 25069
Rat Tnfrsf8 Predicted Functions
Predicted to enable transmembrane signaling receptor activity. Involved in positive regulation of NF-kappaB transcription factor activity. Predicted to be located in plasma membrane. Orthologous to human TNFRSF8 (TNF receptor superfamily member 8).
