HGNC ID: 1762
Target Abstract:
The cadherin superfamily includes numerous cell surface glycoproteins that contain one or more cadherin repeat sequences and are involved in calcium-dependent cell adhesion. Placental cadherin (P-cadherin) is a calcium-dependent adhesion molecule expressed in the placenta, epidermis, and mammary glands. It plays a crucial role in tissue and cellular morphogenesis, growth, and differentiation, and it is instrumental in regulating morphogenesis and maintaining the integrity and polarity of adult tissues. In addition, it has significant implications in the invasion of tumor cells.
CDH3 Target Infomation Overview
- Target Symbol: CDH3, cadherin 3
- Gene Groups: Type I classical cadherins
- Alias: CDHP; PCAD
- Alias Names: P-cadherin; cadherin 3, P-cadherin (placental); cadherin 3, type 1, P-cadherin (placental)
CDH3, cadherin 3 Target Infomation by Species
- Human
- Mouse
- Rat
Human CDH3 Target Information
- Target Symbol: CDH3, cadherin 3
- Alias:
- cadherin 3, type 1, P-cadherin (placental)
- cadherin-3
- calcium-dependent adhesion protein, placental
- CDHP
- HJMD
- PCAD
- NCBI_Gene: 1001
- UniProtKB: P22223
Human CDH3 Predicted Functions
Predicted to enable cadherin binding activity and calcium ion binding activity. Involved in several processes, including negative regulation of timing of catagen; positive regulation of signal transduction; and regulation of gene expression. Located in cell junction and plasma membrane. Implicated in congenital hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome.
Mouse Cdh3 Target Information
- Target Symbol: Cdh3, cadherin 3
- Alias:
- AI385538
- Cadp
- expressed sequence AI385538
- P-cadherin
- Pcad
- placental cadherin
- NCBI_Gene: 12560
Mouse Cdh3 Predicted Functions
Predicted to enable cadherin binding activity and calcium ion binding activity. Acts upstream of or within cell-cell adhesion. Located in adherens junction and plasma membrane. Is expressed in several structures, including alimentary system; embryo ectoderm; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in congenital hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome. Orthologous to human CDH3 (cadherin 3).
Rat Cdh3 Target Information
- Target Symbol: Cdh3, cadherin 3
- Alias:
- cadherin 3, type 1, P-cadherin (placental)
- cadherin-3
- NCBI_Gene: 116777
- UniProtKB: F1LMI3
Rat Cdh3 Predicted Functions
Predicted to enable cadherin binding activity and calcium ion binding activity. Involved in response to xenobiotic stimulus and wound healing. Located in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in congenital hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome. Orthologous to human CDH3 (cadherin 3).
