HGNC ID: 7174
Target Abstract:
Matrix metalloproteinase 7(MMP-7), also known as stromatolysin, is encoded by the MMP7 gene in humans. MMP-7 is usually expressed in epithelial cells, liver, and mammary gland. The expression of MMP-7 is regulated by the Wnt/ β-synprotein signaling pathway, mediated by transforming growth factor β(TGF-β). The primary role of lysed/activated MMP-7 is to break down the extracellular matrix by degrading macromolecules including casein, type I, II, IV, and V gelatin, fibronectin, and proteoglycans. MMP-7 may be involved in tumor metastasis and inflammation. Upregulated MMP-7 is associated with a number of malignancies including cell cancers of the esophagus, stomach, colon, liver, pancreas, and kidney. MMP-7 is highly expressed in advanced colorectal adenomatous polyps with severe dysplasia, and in addition, it is involved in the transformation of colorectal adenomas into a malignant state and promotes their growth.
MMP7 Target Infomation Overview
- Target Symbol: MMP7, matrix metallopeptidase 7
- Gene Groups: M10 matrix metallopeptidases
- Alias: PUMP-1
- Previous Names: MPSL1
- Alias Names: matrilysin; matrix metalloproteinase 7 (matrilysin, uterine)
MMP7, matrix metallopeptidase 7 Target Infomation by Species
- Human
- Mouse
- Rat
Human MMP7 Target Information
- Target Symbol: MMP7, matrix metallopeptidase 7
- Alias:
- matrilysin
- matrin
- matrix metallopeptidase 7 (matrilysin, uterine)
- matrix metalloproteinase 7
- matrix metalloproteinase 7 (matrilysin, uterine)
- matrix metalloproteinase-7
- MMP-7
- MPSL1
- PUMP-1
- pump-1 protease
- uterine matrilysin
- uterine metalloproteinase
- NCBI_Gene: 4316
- UniProtKB: P09237
Human MMP7 Predicted Functions
Enables endopeptidase activity and metallopeptidase activity. Involved in positive regulation of cell migration and proteolysis. Acts upstream of or within membrane protein ectodomain proteolysis and membrane protein intracellular domain proteolysis. Located in extracellular exosome. Biomarker of endometrial cancer; endometrial hyperplasia; glioblastoma; and lung non-small cell carcinoma.
Mouse Mmp7 Target Information
- Target Symbol: Mmp7, matrix metallopeptidase 7
- Alias:
- MAT
- matrilysin
- NCBI_Gene: 17393
Mouse Mmp7 Predicted Functions
Enables peptidase activity. Acts upstream of or within several processes, including defense response to bacterium; proteolysis; and response to xenobiotic stimulus. Predicted to be located in cell surface. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; hemolymphoid system gland; integumental system; liver and biliary system; and reproductive system. Orthologous to human MMP7 (matrix metallopeptidase 7).
Rat Mmp7 Target Information
- Target Symbol: Mmp7, matrix metallopeptidase 7
- Alias:
- matrilysin
- matrin
- matrix metalloproteinase 7
- Matrix metalloproteinase 7 (matrilysin)
- matrix metalloproteinase-7
- MMP-7
- MPMM
- pump-1 protease
- uterine metalloproteinase
- NCBI_Gene: 25335
- UniProtKB: P50280
Rat Mmp7 Predicted Functions
Enables heparin binding activity. Involved in several processes, including cellular response to mechanical stimulus; estrous cycle; and maternal process involved in female pregnancy. Located in cell surface and extracellular space. Used to study hypertension and prostate carcinoma. Biomarker of bladder neck obstruction; coronary restenosis; hypertension; prostate cancer; and renal hypertension. Orthologous to human MMP7 (matrix metallopeptidase 7).
