Matrix metalloproteinase 7(MMP-7), also known as stromatolysin, is encoded by the MMP7 gene in humans. MMP-7 is usually expressed in epithelial cells, liver, and mammary gland. The expression of MMP-7 is regulated by the Wnt/ β-synprotein signaling pathway, mediated by transforming growth factor β(TGF-β). The primary role of lysed/activated MMP-7 is to break down the extracellular matrix by degrading macromolecules including casein, type I, II, IV, and V gelatin, fibronectin, and proteoglycans. MMP-7 may be involved in tumor metastasis and inflammation. Upregulated MMP-7 is associated with a number of malignancies including cell cancers of the esophagus, stomach, colon, liver, pancreas, and kidney. MMP-7 is highly expressed in advanced colorectal adenomatous polyps with severe dysplasia, and in addition, it is involved in the transformation of colorectal adenomas into a malignant state and promotes their growth.