HGNC ID: 16404
Target Abstract:
Interleukin 17F (IL-17F) and IL-17A are two closely related members of the IL-17 family with approximately 50% amino acid homology.IL-17F is derived from different cell types, such as Th17 cells, mast cells, and basophils, and is widely expressed in tissues, including the lung.IL-17F induces a number of cytokines and adhesion molecules in bronchial epithelial cells, vascular endothelial cells, adult fibroblasts, and many cytokines, chemokines, and adhesion molecules in eosinophils.IL-17F utilizes IL-17RA and IL-17RC as its receptors to activate the MAP kinase-related pathway. Overexpression of the IL-17F gene in mouse airways is associated with increased neutrophilia, induction of multiple cytokines, airway hyperresponsiveness, and mucus hypersecretion in the airways. Thus, IL-17F may play an important role in allergic airway inflammation and have important therapeutic implications for asthma.
IL17F Target Infomation Overview
- Target Symbol: IL17F, interleukin 17F
- Gene Groups: Interleukins
- Alias: IL-17F; ML-1; ML1
IL17F, interleukin 17F Target Infomation by Species
- Human
- Mouse
- Rat
Human IL17F Target Information
- Target Symbol: IL17F, interleukin 17F
- Alias:
- CANDF6
- cytokine ML-1
- IL-17F
- IL-24
- interleukin-17F
- interleukin-24
- ML-1
- ML1
- mutant IL-17F
- NCBI_Gene: 112744
- UniProtKB: Q96PD4
Human IL17F Predicted Functions
Enables cytokine activity; cytokine binding activity; and protein homodimerization activity. Involved in several processes, including interleukin-17-mediated signaling pathway; negative regulation of angiogenesis; and regulation of cytokine production. Predicted to be located in extracellular region. Implicated in chronic mucocutaneous candidiasis.
Mouse Il17f Target Information
- Target Symbol: Il17f, interleukin 17F
- Alias:
- C87042
- expressed sequence C87042
- NCBI_Gene: 257630
Mouse Il17f Predicted Functions
Enables cytokine receptor binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in defense response to bacterium and positive regulation of gene expression. Acts upstream of or within positive regulation of cytokine production involved in inflammatory response and positive regulation of transcription by RNA polymerase II. Located in extracellular space. Human ortholog(s) of this gene implicated in chronic mucocutaneous candidiasis. Orthologous to human IL17F (interleukin 17F).
Rat Il17f Target Information
- Target Symbol: Il17f, interleukin 17F
- Alias:
- IL-17F
- interleukin-17F
- LOC301291
- MGC114402
- NCBI_Gene: 301291
Rat Il17f Predicted Functions
Predicted to enable cytokine binding activity; protein dimerization activity; and signaling receptor binding activity. Predicted to be involved in several processes, including defense response to bacterium; interleukin-17-mediated signaling pathway; and regulation of cytokine production. Predicted to act upstream of or within positive regulation of cytokine production involved in inflammatory response and positive regulation of transcription by RNA polymerase II. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in chronic mucocutaneous candidiasis. Orthologous to human IL17F (interleukin 17F).
