HGNC ID: 11809
Target Abstract:
Tyrosine kinase receptor Tie1 is a single transmembrane type I membrane protein belonging to the protein kinase superfamily, the tyrosine kinase family and the Tie subfamily. Tie1 has three EGF-like domains, three fibronectin type III domains, two immunoglobulin-like type C2 domains, and one protein kinase domain. Tie1 is a cell surface protein specifically expressed in endothelial cells; however, studies have shown that it can also be expressed in immature hematopoietic cells and platelets. Tie1 is essential for the survival and growth of microvascular endothelial cells during the capillary emergence phase of vascular development. Tie1 up-regulates the cell adhesion molecules VCAM-1, E-selectin, and ICAM-1 through a P38-dependent mechanism. The expression of Tie1 enhances the adhesion of monocyte-derived immune cells to endothelial cells. Tie1 has a proinflammatory effect and plays an important role in inflammatory diseases of the endothelium such as atherosclerosis.
TIE1 Target Infomation Overview
- Target Symbol: TIE1, tyrosine kinase with immunoglobulin like and EGF like domains 1
- Gene Groups: Receptor tyrosine kinases; Fibronectin type III domain containing; Immunoglobulin like domain containing
- Alias: JTK14
- Previous Names: TIE
- Alias Names: tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1; tyrosine kinase with immunoglobulin-like and EGF-like domains 1
TIE1, tyrosine kinase with immunoglobulin like and EGF like domains 1 Target Infomation by Species
- Human
- Mouse
- Rat
Human TIE1 Target Information
- Target Symbol: TIE1, tyrosine kinase with immunoglobulin like and EGF like domains 1
- Alias:
- JTK14
- LMPHM11
- receptor tyrosine kinase
- soluble TIE1 variant 1
- soluble TIE1 variant 2
- soluble TIE1 variant 3
- soluble TIE1 variant 4
- soluble TIE1 variant 5
- TIE
- tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1
- tyrosine kinase with immunoglobulin-like and EGF-like domains 1
- tyrosine-protein kinase receptor Tie-1
- NCBI_Gene: 7075
- UniProtKB: P35590
Human TIE1 Predicted Functions
Predicted to enable transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in several processes, including circulatory system development; positive regulation of angiogenesis; and positive regulation of kinase activity. Predicted to act upstream of or within several processes, including negative regulation of angiogenesis; plasma membrane fusion; and vasculature development. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Implicated in hereditary lymphedema.
Mouse Tie1 Target Information
- Target Symbol: Tie1, tyrosine kinase with immunoglobulin-like and EGF-like domains 1
- Alias:
- D430008P04Rik
- RIKEN cDNA D430008P04 gene
- TIE
- tie-1
- NCBI_Gene: 21846
Mouse Tie1 Predicted Functions
Predicted to enable transmembrane receptor protein tyrosine kinase activity. Involved in circulatory system development; response to retinoic acid; and tissue remodeling. Acts upstream of or within several processes, including negative regulation of angiogenesis; plasma membrane fusion; and vasculature development. Located in plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; extraembryonic component; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human TIE1 (tyrosine kinase with immunoglobulin like and EGF like domains 1).
Rat Tie1 Target Information
- Target Symbol: Tie1, tyrosine kinase with immunoglobulin-like and EGF-like domains 1
- Alias:
- tyrosine kinase receptor 1
- tyrosine-protein kinase receptor Tie-1
- NCBI_Gene: 89806
- UniProtKB: B5DFD6
Rat Tie1 Predicted Functions
Predicted to enable transmembrane receptor protein tyrosine kinase activity. Involved in vasculogenesis. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human TIE1 (tyrosine kinase with immunoglobulin like and EGF like domains 1).
