HGNC ID: 1681
Target Abstract:
CD44 is a cell surface glycoprotein that participates in cell-cell interactions, cell adhesion, and cell migration. CD44 is normally expressed in all blood cells (excluding platelets) and non-hematopoietic tissues, but is not expressed in normal liver cells, whereas it is expressed in biliary epithelium. Abnormal expression of CD44 has been found in multiple myeloma cells, most lymphomas, chronic lymphocytic leukemia, and tumorous mast cells. CD44 mainly participates in the activation of lymphocytes, binding to extracellular matrix molecules such as hyaluronic acid and laminin, and mediating the binding of lymphocytes to high endothelial venules in postcapillary venules, allowing lymphocytes to cross the vascular wall and return to lymphoid tissue.
CD44 Target Infomation Overview
- Target Symbol: CD44, CD44 molecule (Indian blood group)
- Gene Groups: Blood group antigens; CD molecules; Proteoglycans
- Alias: IN; MC56; Pgp1; CD44R; HCELL; CSPG8
- Previous Names: MIC4; MDU2; MDU3
- Alias Names: hematopoietic cell E- and L-selectin ligand; chondroitin sulfate proteoglycan 8; CD44 antigen (homing function and Indian blood group system)
CD44, CD44 molecule (Indian blood group) Target Infomation by Species
- Human
- Mouse
- Rat
Human CD44 Target Information
- Target Symbol: CD44, CD44 molecule (Indian blood group)
- Alias:
- CD44 antigen
- CDW44
- cell surface glycoprotein CD44
- chondroitin sulfate proteoglycan 8
- CSPG8
- ECMR-III
- epican
- extracellular matrix receptor III
- GP90 lymphocyte homing/adhesion receptor
- HCELL
- hematopoietic cell E- and L-selectin ligand
- heparan sulfate proteoglycan
- Hermes antigen
- homing function and Indian blood group system
- HUTCH-I
- hyaluronate receptor
- IN
- Indian blood group antigen
- LHR
- MC56
- MDU2
- MDU3
- MGC10468
- MIC4
- MUTCH-I
- Pgp1
- phagocytic glycoprotein 1
- soluble CD44
- NCBI_Gene: 960
- UniProtKB: P16070
Human CD44 Predicted Functions
Enables hyaluronic acid binding activity. Contributes to cytokine receptor activity. Involved in several processes, including positive regulation of cell-cell adhesion; positive regulation of phosphorylation; and regulation of intracellular signal transduction. Located in several cellular components, including Golgi apparatus; apical plasma membrane; and lamellipodium membrane. Part of macrophage migration inhibitory factor receptor complex. Implicated in breast carcinoma (multiple); carcinoma (multiple); and prostate cancer. Biomarker of Krukenberg carcinoma; invasive ductal carcinoma; leiomyomatosis; lung adenocarcinoma; and urinary system cancer (multiple).
Mouse Cd44 Target Information
- Target Symbol: Cd44, CD44 antigen
- Alias:
- AU023126
- AW121933
- AW146109
- expressed sequence AU023126
- expressed sequence AW121933
- expressed sequence AW146109
- HERMES
- Ly-24
- lymphocyte antigen 24
- Pgp-1
- phagocyte glycoprotein 1
- NCBI_Gene: 12505
Mouse Cd44 Predicted Functions
Enables hyaluronic acid binding activity and type II transforming growth factor beta receptor binding activity. Contributes to cytokine binding activity and cytokine receptor activity. Involved in several processes, including negative regulation of T cell activation; positive regulation of protein phosphorylation; and regulation of intracellular signal transduction. Acts upstream of or within several processes, including Wnt signaling pathway; morphogenesis of a branching epithelium; and wound healing involved in inflammatory response. Located in basolateral plasma membrane; external side of plasma membrane; and microvillus. Part of macrophage migration inhibitory factor receptor complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and limb. Human ortholog(s) of this gene implicated in breast carcinoma (multiple); carcinoma (multiple); and prostate cancer. Orthologous to human CD44 (CD44 molecule (Indian blood group)).
Rat Cd44 Target Information
- Target Symbol: Cd44, CD44 molecule (Indian blood group)
- Alias:
- CD44 antigen
- CD44 antigen isoform d6-12
- CD44 antigen isoform d6-13
- CD44 antigen isoform d6-15
- Cd44 molecule
- CD44A
- cell surface glycoprotein CD44 (hyaluronate binding protein)
- ECMR-III
- extracellular matrix receptor III
- GP90 lymphocyte homing/adhesion receptor
- hermes antigen
- HUTCH-I
- hyaluronate receptor
- METAA
- MGC124941
- PGP-1
- PGP-I
- phagocytic glycoprotein 1
- phagocytic glycoprotein I
- RHAMM
- NCBI_Gene: 25406
Rat Cd44 Predicted Functions
Enables epidermal growth factor receptor binding activity; phosphoprotein binding activity; and protein kinase binding activity. Involved in several processes, including blood vessel maturation; macrophage fusion; and positive regulation of neutrophil apoptotic process. Located in apical plasma membrane; basolateral plasma membrane; and nucleus. Part of protein-containing complex. Biomarker of borna disease and cholestasis. Human ortholog(s) of this gene implicated in breast carcinoma (multiple); carcinoma (multiple); and prostate cancer. Orthologous to human CD44 (CD44 molecule (Indian blood group)).