HGNC ID: 1698
Target Abstract:
CD79a, also known as mb-1, is a 47kDa transmembrane glycoprotein that forms a heterodimer with CD79b to constitute the B cell receptor (BCR). This receptor is responsible for signal transduction in B cells, leading to activation, apoptosis, or allergy. CD79a expression is present from the earliest B cells to plasma cells. It is expressed in B cell tumors and some non-B cell malignancies such as AML. Unlike other antibodies that can be expressed in B cell tumor cells, HM47 is a reliable antibody for recognizing CD79a, making it a good marker for B cells. Due to the presence of several variants of CD79a, the exact location of the epitope may vary slightly.
CD79A Target Infomation Overview
- Target Symbol: CD79A, CD79a molecule
- Gene Groups: CD molecules; V-set domain containing
- Alias: MB-1
- Previous Names: IGA
- Alias Names: B-cell antigen receptor complex-associated protein alpha chain; CD79A antigen (immunoglobulin-associated alpha); CD79a molecule, immunoglobulin-associated alpha
CD79A, CD79a molecule Target Infomation by Species
- Human
- Mouse
- Rat
Human CD79A Target Information
- Target Symbol: CD79A, CD79a molecule
- Alias:
- B-cell antigen receptor complex-associated protein alpha chain
- CD79a antigen (immunoglobulin-associated alpha)
- CD79a molecule, immunoglobulin-associated alpha
- ig-alpha
- IGA
- MB-1
- MB-1 membrane glycoprotein
- membrane-bound immunoglobulin-associated protein
- surface IgM-associated protein
- NCBI_Gene: 973
- UniProtKB: P11912
Human CD79A Predicted Functions
Enables identical protein binding activity. Predicted to be involved in B cell differentiation; B cell proliferation; and B cell receptor signaling pathway. Predicted to be located in membrane raft and multivesicular body. Predicted to be part of B cell receptor complex. Predicted to be active in external side of plasma membrane. Implicated in agammaglobulinemia.
Mouse Cd79a Target Information
- Target Symbol: Cd79a, CD79A antigen (immunoglobulin-associated alpha)
- Alias:
- aimmunoglobulin-associated alpha
- CD79a antigen
- Ig alpha
- Ig-alpha
- Iga
- Igalpha
- immunoglobulin-associated alpha
- Ly-54
- Ly54
- lymphocyte antigen 54
- mb-1
- NCBI_Gene: 12518
Mouse Cd79a Predicted Functions
Predicted to enable identical protein binding activity. Involved in B cell differentiation and B cell proliferation. Acts upstream of or within B cell receptor signaling pathway. Located in external side of plasma membrane; membrane raft; and multivesicular body. Part of B cell receptor complex. Is expressed in liver. Human ortholog(s) of this gene implicated in agammaglobulinemia. Orthologous to human CD79A (CD79a molecule).
Rat Cd79a Target Information
- Target Symbol: Cd79a, CD79a molecule
- Alias:
- -cell antigen receptor complex-associated protein alpha chain-like
- B-cell antigen receptor complex-associated protein alpha chain
- B-cell antigen receptor complex-associated protein alpha chain-like
- CD79A antigen (immunoglobulin-associated alpha)
- Cd79a molecule-like
- Cd79a molecule, immunoglobulin-associated alpha
- Cd79al
- LOC100913063
- NCBI_Gene: 100913063
Rat Cd79a Predicted Functions
Predicted to enable identical protein binding activity. Predicted to be involved in B cell differentiation and B cell proliferation. Predicted to act upstream of or within B cell receptor signaling pathway. Predicted to be located in external side of plasma membrane; membrane raft; and multivesicular body. Predicted to be part of B cell receptor complex. Human ortholog(s) of this gene implicated in agammaglobulinemia. Orthologous to human CD79A (CD79a molecule).
