HGNC ID: 4602
Target Abstract:
Chemokine (C-X-C motif) ligand 1 (CXCL1) is a small molecular weight cytokine belonging to the CXC family of chemokines, formerly also known as GRO1 oncogene, GROα, KC, and neutrophil-activating protein 3 (NAP-3). In humans, this protein is encoded by the CXCL1 gene.CXCL1 is secreted by human melanoma cells, has mitogenic properties, and has been implicated in melanoma pathogenesis.CXCL1 is expressed by macrophages, neutrophils, and epithelial cells and has neutrophil chemotactic activity. This chemokine signals through the chemokine receptor CXCR2, which triggers its effects.CXCL1 acts on spinal cord development by inhibiting the migration of oligodendrocyte precursors. It is involved in vascular growth, inflammation, wound healing and tumorigenesis. Preliminary studies in mice suggest that CXCL1 reduces the severity of multiple sclerosis and may provide neuroprotection.
CXCL1 Target Infomation Overview
- Target Symbol: CXCL1, C-X-C motif chemokine ligand 1
- Gene Groups: Chemokine ligands
- Alias: SCYB1; GROa; MGSA-a; NAP-3
- Previous Names: MGSA; GRO1; FSP
- Alias Names: melanoma growth stimulating activity, alpha; GRO1 oncogene (melanoma growth stimulating activity, alpha); fibroblast secretory protein; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL1, C-X-C motif chemokine ligand 1 Target Infomation by Species
- Human
- Mouse
- Rat
Human CXCL1 Target Information
- Target Symbol: CXCL1, C-X-C motif chemokine ligand 1
- Alias:
- C-X-C motif chemokine 1
- chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
- fibroblast secretory protein
- FSP
- GRO-alpha(1-73)
- GRO1
- GRO1 oncogene (melanoma growth stimulating activity, alpha)
- GRO1 oncogene (melanoma growth-stimulating activity)
- GROa
- growth-regulated alpha protein
- melanoma growth stimulating activity, alpha
- melanoma growth stimulatory activity alpha
- MGSA
- MGSA alpha
- MGSA-a
- NAP-3
- neutrophil-activating protein 3
- SCYB1
- NCBI_Gene: 2919
- UniProtKB: P09341
Human CXCL1 Predicted Functions
Predicted to enable CXCR chemokine receptor binding activity and chemokine activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide and killing of cells of other organism. Predicted to be located in extracellular region; specific granule lumen; and tertiary granule lumen. Predicted to be active in extracellular space. Biomarker of asthma; chronic obstructive pulmonary disease; common cold; cystic fibrosis; and hyperhomocysteinemia.
Mouse Cxcl1 Target Information
- Target Symbol: Cxcl1, chemokine (C-X-C motif) ligand 1
- Alias:
- fibroblast secretory protein
- Fsp
- Gro1
- GRO1 oncogene
- KC
- KC/GRO-alpha
- melanoma growth stimulatory activity
- Mgsa
- N51
- Scyb1
- NCBI_Gene: 14825
Mouse Cxcl1 Predicted Functions
Predicted to enable CXCR chemokine receptor binding activity and chemokine activity. Involved in positive regulation of hematopoietic stem cell proliferation; positive regulation of neutrophil mediated killing of fungus; and positive regulation of superoxide anion generation. Located in extracellular space. Is expressed in several structures, including gonad; liver; lung; nervous system; and retina. Orthologous to human CXCL2 (C-X-C motif chemokine ligand 2).
Rat Cxcl1 Target Information
- Target Symbol: Cxcl1, C-X-C motif chemokine ligand 1
- Alias:
- C-X-C motif chemokine 1
- chemokine (C-X-C motif) ligand 1
- chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
- CINC-1
- cytokine-induced neutrophil chemoattractant 1
- Gro
- Gro1
- growth-regulated alpha protein
- platelet-derived growth factor-inducible protein KC
- NCBI_Gene: 81503
Rat Cxcl1 Predicted Functions
Enables chemokine activity. Involved in several processes, including neutrophil chemotaxis; positive regulation of ion transport; and response to amphetamine. Located in extracellular space. Biomarker of several diseases, including acute necrotizing pancreatitis; pneumonia (multiple); prostatitis; severe acute respiratory syndrome; and status epilepticus. Orthologous to human CXCL1 (C-X-C motif chemokine ligand 1); CXCL2 (C-X-C motif chemokine ligand 2); and CXCL3 (C-X-C motif chemokine ligand 3).
