HGNC ID: 9445
Target Abstract:
Prolactin (PRL) is a neuroendocrine pituitary hormone encoded by the PRL gene that is synthesized by the pituitary gland, placenta, brain, uterus, dermal fibroblasts, meconium, B cells, T cells, natural killer cells, and breast cancer cells. Prolactin is expressed at low levels in early human gestation, is replaced by placental prolactin, and increases in late gestation. Prolactin plays an important role in metabolism, immune system regulation, and pancreatic development. Prolactin also acts in a cytokine-like manner and is an important regulator of the immune system. Prolactin has important cell cycle-related functions as a growth, differentiation and anti-apoptotic factor. As a growth factor that binds to cytokine-like receptors, it affects hematopoiesis, angiogenesis, and the regulation of blood coagulation through a variety of pathways.
PRL Target Infomation Overview
- Target Symbol: PRL, prolactin
- Gene Groups: Growth hormone family; Neuropeptides
PRL, prolactin Target Infomation by Species
- Human
- Mouse
- Rat
Human PRL Target Information
- Target Symbol: PRL, prolactin
- Alias:
- decidual prolactin
- GHA1
- growth hormone A1
- NCBI_Gene: 5617
- UniProtKB: P01236
Human PRL Predicted Functions
Predicted to enable hormone activity and prolactin receptor binding activity. Involved in several processes, including negative regulation of endothelial cell proliferation; positive regulation of pri-miRNA transcription by RNA polymerase II; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in secretory granule. Predicted to be active in extracellular space. Implicated in carotid artery disease. Biomarker of hepatocellular carcinoma; hypoglycemia; obesity; and severe acute respiratory syndrome.
Mouse Prl Target Information
- Target Symbol: Prl, prolactin
- Alias:
- AV290867
- expressed sequence AV290867
- Prl1a1
- NCBI_Gene: 19109
Mouse Prl Predicted Functions
Predicted to enable hormone activity and prolactin receptor binding activity. Acts upstream of or within several processes, including mammary gland development; maternal behavior; and positive regulation of receptor signaling pathway via JAK-STAT. Located in secretory granule. Is expressed in hippocampus; pituitary gland; placenta; and trophoblast giant cell. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human PRL (prolactin).
Rat Prl Target Information
- Target Symbol: Prl, prolactin
- Alias:
- Gha1
- growth hormone a1
- Prl1a1
- PRLB
- PRLSD1
- Prol
- prolactin family 1, subfamily a, member 1
- RATPRLSD1
- RNPROL
- NCBI_Gene: 24683
Rat Prl Predicted Functions
Predicted to enable hormone activity and prolactin receptor binding activity. Involved in several processes, including parturition; response to estradiol; and response to lipopolysaccharide. Located in extracellular region and secretory granule. Used to study portal hypertension and prolactinoma. Biomarker of hyperprolactinemia; prolactinoma; and renovascular hypertension. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human PRL (prolactin).
