Target Abstract: S100A1 is a Ca2+ binding protein of the EF-hand type that belongs to the S100 protein family. S100 proteins consisting of at least 19 members exist as dimers in the cytoplasm and/or nucleus of a wide range of cells, and are involved in the regulation of a number of cellular processes such as cell-cycle progression and cell differentiation. This protein has been shown to function in the processes including stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of PKC-mediated phosphorylation. Phosphoglucomutase is a target protein whose activity is antagonistically regulated by S100A1, and recently, S100A1 is also identified as a potent molecular chaperone and a new member of the Hsp70/Hsp90 multichaperone complex. S100A1 displays a tissue-specific expression pattern with highest levels in myocardium and is considered to be an important regulator of cardiac contractility. Accordingly, reduced expression or mutations of S100A1 gene have been implicated in cardiomyopathies.
S100A1 Target Infomation Overview
- Target Symbol: S100A1, S100 calcium binding protein A1
- Gene Groups: S100 calcium binding proteins; EF-hand domain containing
- Alias: S100-alpha, S100A
- Alias Names: S100 calcium-binding protein A1
S100A1, epidermal growth factor receptor Target Infomation by Species
- Human
- Mouse
- Rat
Human S100A1 Target Information
- Target Symbol: S100A1, S100 calcium binding protein A1
- Alias:
- protein S100-A1
- S-100 protein alpha chain
- S-100 protein subunit alpha
- S100
- S100 alpha
- S100 calcium-binding protein A1
- S100 protein, alpha polypeptide
- S100-alpha
- S100A
- NCBI_Gene: 6271
- UniProtKB: P23297
Human S100A1 Predicted Functions
Enables ATPase binding activity; S100 protein binding activity; and protein homodimerization activity. Involved in positive regulation of nitric-oxide synthase activity and positive regulation of sprouting angiogenesis. Located in several cellular components, including Golgi apparatus; nucleoplasm; and sarcoplasmic reticulum.
Mouse S100a1 Target Information
- Target Symbol: S100a1, S100 calcium binding protein A1
- Alias:
- AI266795
- expressed sequence AI266795
- S100
- S100a
- NCBI_Gene: 20193
Mouse S100a1 Predicted Functions
Predicted to enable several functions, including ATPase binding activity; S100 protein binding activity; and protein homodimerization activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; positive regulation of nitric-oxide synthase activity; and positive regulation of sprouting angiogenesis. Located in sarcoplasmic reticulum. Is expressed in several structures, including brain; heart; inner ear; musculature; and urothelium. Orthologous to human S100A1 (S100 calcium binding protein A1).
Rat S100a1 Target Information
- Target Symbol: S100a1, S100 calcium binding protein A1
- Alias:
- protein S100-A1
- S-100 protein alpha chain
- S-100 protein subunit alpha
- S100 calcium-binding protein A1
- NCBI_Gene: 295214
Rat S100a1 Predicted Functions
Enables calcium ion binding activity; calcium-dependent protein binding activity; and identical protein binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of voltage-gated calcium channel activity. Located in M band and Z disc. Orthologous to human S100A1 (S100 calcium binding protein A1).
