HGNC ID: 11935
Target Abstract:
The CD40 ligand (CD40L/CD154) is a member of the TNF superfamily, a 39kDa glycoprotein that is mainly expressed in activated T cells. Soluble CD40L(sCD40L) with a molecular weight of 15-18 KDa is produced by proteolysis. CD40L binds to CD40 on the surface of antigen presenting cells (APC) to produce a variety of effects depending on the target cell type. As a co-stimulatory molecule, CD40L is particularly important for T cell subpopulation follicular T helper cells (Tfh cells). In Tfh cells, CD40L binds to CD40 on the surface of B cells to promote B cell maturation and function, thus promoting cell-to-cell connections. Deletion of the CD40L gene results in the inability of immunoglobulin type switching and is associated with hyperigm syndrome. Loss of CD40L also blocks germinal center formation, thus preventing an important process in the adaptive immune system called antibody affinity maturation.
CD40LG Target Infomation Overview
- Target Symbol: CD40LG, CD40 ligand
- Gene Groups: CD molecules; Tumor necrosis factor superfamily
- Alias: CD40L; TRAP; gp39; hCD40L; CD154
- Previous Names: HIGM1; IMD3; TNFSF5
- Alias Names: CD40 antigen ligand; tumor necrosis factor (ligand) superfamily member 5; T-B cell-activating molecule; TNF-related activation protein; hyper-IgM syndrome; tumor necrosis factor (ligand) superfamily, member 5 (hyper-IgM syndrome)
CD40LG, CD40 ligand Target Infomation by Species
- Human
- Mouse
- Rat
Human CD40LG Target Information
- Target Symbol: CD40LG, CD40 ligand
- Alias:
- CD154
- CD40 antigen ligand
- CD40-L
- CD40L
- gp39
- hCD40L
- HIGM1
- IGM
- IMD3
- T-B cell-activating molecule
- T-BAM
- T-cell antigen Gp39
- TNF-related activation protein
- TNFSF5
- TRAP
- tumor necrosis factor (ligand) superfamily member 5
- NCBI_Gene: 959
- UniProtKB: P29965
Human CD40LG Predicted Functions
Enables CD40 receptor binding activity and integrin binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of cytokine production; and regulation of apoptotic process. Located in cell surface. Implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); combined T cell and B cell immunodeficiency (multiple); hematologic cancer (multiple); and lupus nephritis. Biomarker of several diseases, including allergic rhinitis; autoimmune disease (multiple); cardiovascular system disease (multiple); diabetes mellitus (multiple); and hematologic cancer (multiple).
Mouse Cd40lg Target Information
- Target Symbol: Cd40lg, CD40 ligand
- Alias:
- CD154
- CD40 antigen ligand
- Cd40l
- Cd40L
- gp39
- HIGM1
- IMD3
- Ly-62
- Ly62
- lymphocyte antigen 62
- T-BAM
- Tnfsf5
- tumor necrosis factor (ligand) superfamily, member 5
- NCBI_Gene: 21947
Mouse Cd40lg Predicted Functions
Predicted to enable CD40 receptor binding activity and integrin binding activity. Involved in isotype switching. Acts upstream of or within B cell differentiation and regulation of immunoglobulin production. Located in external side of plasma membrane. Is expressed in Meckel’s cartilage; dorsal root ganglion; and limb. Used to study inflammatory bowel disease and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; artery disease (multiple); autoimmune disease (multiple); combined T cell and B cell immunodeficiency (multiple); and hematologic cancer (multiple). Orthologous to human CD40LG (CD40 ligand).
Rat Cd40lg Target Information
- Target Symbol: Cd40lg, CD40 ligand
- Alias:
- CD40 ligand CD154
- CD40-L
- Cd40l
- LOC84349
- Tnfsf5
- tumor necrosis factor (ligand) superfamily, member 5
- tumor necrosis factor ligand superfamily member 5
- NCBI_Gene: 84349
Rat Cd40lg Predicted Functions
Enables CD40 receptor binding activity. Involved in several processes, including positive regulation of B cell proliferation; positive regulation of MHC class II biosynthetic process; and positive regulation of cytokine production. Located in several cellular components, including cell body; cell surface; and extracellular space. Used to study Ehrlich tumor carcinoma; artery disease (multiple); autoimmune disease (multiple); thrombosis; and vitamin B12 deficiency. Biomarker of atherosclerosis; coronary artery disease; perinatal necrotizing enterocolitis; periodontal disease; and pulmonary hypertension. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); combined T cell and B cell immunodeficiency (multiple); hematologic cancer (multiple); and lupus nephritis. Orthologous to human CD40LG (CD40 ligand).
