HGNC ID: 12682
Target Abstract:
Vascular endothelial growth factor C (VEGF-C) is a dimeric secreted protein, a member of the PDGF/VEGF family. Translated VEGF-C has three structural domains: the middle VEGF homology domain (VHD), the N-terminal structural domain (prepeptide), and the C-terminal structural domain (pre-peptide).VEGF-C has an important role in lymphangiogenesis and acts on lymphatic vessel endothelial cells mainly by binding to its receptor, VEGFR-3, thereby promoting their survival, growth, and migration. Studies have demonstrated that VEGF-C is a specific growth factor for lymphatic vessels in a variety of models.In addition to its effects on lymphatic vessels, VEGF-C promotes vascular growth and regulates vascular permeability by binding to its primary receptor, VEGFR-3, or secondary receptor, VEGFR-2. In addition, VEGF-C is important for neural development and blood pressure regulation. Deficiency of VEGF-C leads to lymphedema, while excess VEGF-C is associated with tumor angiogenesis and metastasis.
VEGFC Target Infomation Overview
- Target Symbol: VEGFC, vascular endothelial growth factor C
- Gene Groups: VEGF family
- Alias: VRP; VEGF-C
- Alias Names: vascular endothelial growth factor-related protein
VEGFC, vascular endothelial growth factor C Target Infomation by Species
- Human
- Mouse
- Rat
Human VEGFC Target Information
- Target Symbol: VEGFC, vascular endothelial growth factor C
- Alias:
- FLT4 ligand DHM
- Flt4-L
- LMPH1D
- LMPHM4
- vascular endothelial growth factor-related protein
- VEGF-C
- VRP
- NCBI_Gene: 7424
- UniProtKB: P49767
Human VEGFC Predicted Functions
Enables chemoattractant activity and vascular endothelial growth factor receptor 3 binding activity. Involved in induction of positive chemotaxis; positive regulation of mast cell chemotaxis; and vascular endothelial growth factor receptor signaling pathway. Predicted to be located in extracellular region and platelet alpha granule lumen. Predicted to be active in extracellular space. Implicated in breast carcinoma and hereditary lymphedema ID. Biomarker of several diseases, including invasive ductal carcinoma; liver disease (multiple); papillary carcinoma; pterygium; and urinary system cancer (multiple).
Mouse Vegfc Target Information
- Target Symbol: Vegfc, vascular endothelial growth factor C
- Alias:
- AW228853
- expressed sequence AW228853
- VEGF-C
- NCBI_Gene: 22341
Mouse Vegfc Predicted Functions
Enables vascular endothelial growth factor receptor 3 binding activity. Involved in several processes, including negative regulation of osteoblast differentiation; positive regulation of angiogenesis; and positive regulation of mesenchymal stem cell proliferation. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; positive regulation of lymphangiogenesis; and positive regulation of peptidyl-tyrosine phosphorylation. Located in extracellular space. Is expressed in several structures, including alimentary system mesentery; brain; cardiovascular system; embryo mesenchyme; and genitourinary system. Used to study hereditary lymphedema. Human ortholog(s) of this gene implicated in breast carcinoma and hereditary lymphedema ID. Orthologous to human VEGFC (vascular endothelial growth factor C).
Rat Vegfc Target Information
- Target Symbol: Vegfc, vascular endothelial growth factor C
- Alias:
- flt4 ligand
- flt4-L
- vascular endothelial growth factor-related protein
- VEGF-C
- VRP
- NCBI_Gene: 114111
- UniProtKB: O35757
Rat Vegfc Predicted Functions
Enables vascular endothelial growth factor receptor 3 binding activity. Involved in several processes, including positive regulation of blood vessel endothelial cell migration; positive regulation of protein autophosphorylation; and regulation of vascular endothelial growth factor receptor signaling pathway. Acts upstream of or within positive regulation of neuroblast proliferation. Predicted to be located in membrane. Predicted to be active in extracellular space. Biomarker of colon adenocarcinoma. Human ortholog(s) of this gene implicated in breast carcinoma and hereditary lymphedema ID. Orthologous to human VEGFC (vascular endothelial growth factor C).
